Detailed information of TA system TA077674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1741651..1742564
• Replicon: chromosome
• Accession: NZ_CP021851
• Organism: Enterobacter cloacae strain A1137

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CCL06_RS08485
• Protein ID: WP_025756032.1
• Coordinates: 1741651..1742124 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A443XYK2
• Locus tag: CCL06_RS08490
• Protein ID: WP_025756031.1
• Coordinates: 1742121..1742564 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCL06_RS08470	1738454..1738675	-	222	WP_008499993.1	cold shock-like protein CspD	-
CCL06_RS08475	1738943..1739263	+	321	WP_006174393.1	ATP-dependent Clp protease adapter ClpS	-
CCL06_RS08480	1739291..1741570	+	2280	WP_025756033.1	ATP-dependent Clp protease ATP-binding subunit ClpA	-
CCL06_RS08485	1741651..1742124	-	474	WP_025756032.1	RES domain-containing protein	Toxin
CCL06_RS08490	1742121..1742564	-	444	WP_025756031.1	DUF2384 domain-containing protein	Antitoxin
CCL06_RS08495	1743154..1743477	+	324	WP_050597145.1	hypothetical protein	-
CCL06_RS08500	1743452..1744255	-	804	WP_025756029.1	DUF4225 domain-containing protein	-
CCL06_RS08505	1744844..1745062	-	219	WP_002211347.1	translation initiation factor IF-1	-
CCL06_RS08510	1745347..1746051	-	705	WP_025756028.1	leucyl/phenylalanyl-tRNA--protein transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-136)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17589.09 Da
• Isoelectric Point: 5.9653

>T77674 WP_025756032.1 NZ_CP021851:c1742124-1741651 [Enterobacter cloacae]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTTISLASLEILVHVKKDTVLNQYQLFSIDIPDEQIDYLDKA
WLPDDWQENPAPVSTMDLGTGWLQSRSALALILPSCIIPYENNAILNPLHPAFHQILGTVKPLPFIFDPRLAEKTAP

Nucleotide

• Length: 474 bp

>T77674 NZ_CP021851:c1742124-1741651 [Enterobacter cloacae]
ATGATTTTTTATCGGCTGGTGACGGGACGCTACGCCAGCGAAGCGTGGAGTGGAAGCGGTGCAAACCAGTATGGCGGGCG
CTGGAATCATAAGGGGCATCCTGCCGTGTATGTTTCCACCACCATCTCGCTGGCATCGCTGGAAATTCTGGTACATGTCA
AAAAAGACACCGTGCTGAATCAGTACCAGCTGTTTAGCATCGATATCCCGGATGAGCAGATTGATTATCTGGACAAAGCA
TGGCTGCCCGATGACTGGCAGGAGAACCCGGCACCGGTCTCAACGATGGATCTGGGCACCGGTTGGCTACAATCCCGCAG
CGCGCTGGCGCTTATCCTGCCTTCCTGCATTATTCCTTACGAAAATAACGCCATACTTAATCCATTACATCCGGCGTTTC
ATCAGATACTGGGTACAGTTAAGCCACTCCCGTTTATTTTTGATCCTCGCCTGGCAGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16353.62 Da
• Isoelectric Point: 8.6039

>AT77674 WP_025756031.1 NZ_CP021851:c1742564-1742121 [Enterobacter cloacae]
MRTWVPAQKPADNALWRFAGLPANRGMRLVEYLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKDDAWTWLQSPVRGLGNRAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT77674 NZ_CP021851:c1742564-1742121 [Enterobacter cloacae]
ATGAGAACATGGGTTCCTGCGCAGAAGCCTGCTGATAACGCGCTCTGGCGATTTGCGGGGTTACCTGCAAACCGGGGTAT
GCGGTTGGTTGAGTATCTCAATCAGGGGTTACCCGTTAGCGTCCTCGACAATATCCACGAGTGGACGGCGATGTCGAAAG
CGGACATCCTGCGCGTGACGGGGATTAACGAACGTAACGTCGCGCGCCGCAAAAGCGCGGGCCGTACGCTGACCCCAGAT
GAAAGCGAACGCGTGGCGCGTTTCGTTCGGGTGCTGGATGCTGCCGTCGATTACTTTGGCAGTAAAGACGACGCCTGGAC
CTGGCTGCAATCTCCGGTGCGAGGGTTAGGGAACAGAGCACCTGTCGATTTAATTGCGACAGAAACCGGCGCGCTGGAAG
TGACCGATTTGATTGGTCGGCTTGAACACGGTGTGTTTGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A443XYK2