Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 252368..252964 Replicon chromosome
Accession NZ_CP021851
Organism Enterobacter cloacae strain A1137

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1ASC9
Locus tag CCL06_RS01235 Protein ID WP_025759000.1
Coordinates 252662..252964 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0F1AUP1
Locus tag CCL06_RS01230 Protein ID WP_013095028.1
Coordinates 252368..252655 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCL06_RS01225 250740..252371 + 1632 WP_025759001.1 Na/Pi cotransporter family protein -
CCL06_RS01230 252368..252655 - 288 WP_013095028.1 putative addiction module antidote protein Antitoxin
CCL06_RS01235 252662..252964 - 303 WP_025759000.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCL06_RS01240 253161..254030 + 870 WP_023621411.1 23S rRNA pseudouridine(2604) synthase RluF -
CCL06_RS01245 254098..255042 - 945 WP_025758999.1 ketopantoate/pantoate/pantothenate transporter PanS -
CCL06_RS01250 255136..256485 - 1350 WP_025758998.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11429.29 Da        Isoelectric Point: 9.7343

>T77670 WP_025759000.1 NZ_CP021851:c252964-252662 [Enterobacter cloacae]
MKEIVQTESFRRWEQNLKDRRARTIIASRLFRLANGLAGDIKPVGEGICELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQAKDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T77670 NZ_CP021851:c252964-252662 [Enterobacter cloacae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCAAGGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACATAAAACCCGTGGGGGAAGGTATATGCGAGCTGAGGATCC
ACTTTGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAAAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10070.62 Da        Isoelectric Point: 5.7807

>AT77670 WP_013095028.1 NZ_CP021851:c252655-252368 [Enterobacter cloacae]
MHKLTPYDPAIALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPAGD

Download         Length: 288 bp

>AT77670 NZ_CP021851:c252655-252368 [Enterobacter cloacae]
ATGCATAAATTAACACCCTACGATCCAGCCATCGCGTTGGTGGATGATGAGGAAATAGCCGTGTTTATGGCTGATGCATT
AGAAACTGGTGACTCTGCGTATATTGCTAAAGCTTTGGGCGTCATCGCGCGAGCGAAAGGGATGTCGACCATTTCACAGC
AAACTGGACTGTCACGAGAACAACTGTACCGATCATTTAGTGATAAGGGGAACCCAACGCTTAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTCACAATCAAACCCGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1ASC9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F1AUP1

References