Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1301462..1302096 Replicon chromosome
Accession NZ_CP021850
Organism Pseudoclostridium thermosuccinogenes strain DSM 5807

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CDO33_RS05615 Protein ID WP_103080159.1
Coordinates 1301462..1301845 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CDO33_RS05620 Protein ID WP_202849473.1
Coordinates 1301845..1302096 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO33_RS05600 1297191..1298858 + 1668 WP_103080156.1 ribonuclease J -
CDO33_RS05605 1298924..1300183 - 1260 WP_103080157.1 nucleotidyltransferase -
CDO33_RS05610 1300646..1301089 + 444 WP_103080158.1 DUF2383 domain-containing protein -
CDO33_RS05615 1301462..1301845 - 384 WP_103080159.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CDO33_RS05620 1301845..1302096 - 252 WP_202849473.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDO33_RS05625 1302577..1302696 - 120 WP_103080161.1 cyclic lactone autoinducer peptide -
CDO33_RS05630 1302699..1303517 - 819 WP_133158673.1 hypothetical protein -
CDO33_RS05635 1303881..1304000 - 120 WP_103080163.1 cyclic lactone autoinducer peptide -
CDO33_RS05640 1304002..1304970 - 969 WP_133158674.1 hypothetical protein -
CDO33_RS20770 1305520..1306554 - 1035 WP_161496430.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-116)

Antitoxin

Antitoxin PemI-like

(4-81)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14016.11 Da        Isoelectric Point: 5.8508

>T77665 WP_103080159.1 NZ_CP021850:c1301845-1301462 [Pseudoclostridium thermosuccinogenes]
MADIPERGAFIVLNFNPQAGHEQAGRRNAIVLSPKEFNRKTGFVVVCPITNQKKGYPFEVDLPVNGIFLDSGGSPITGVI
LTDQVKSLDWTARNIKILKNYDPNDAQIKEIDAIIDECLAKIATYLT

Download         Length: 384 bp

>T77665 NZ_CP021850:c1301845-1301462 [Pseudoclostridium thermosuccinogenes]
ATGGCAGATATACCTGAGAGAGGTGCTTTTATTGTTTTAAACTTTAATCCACAAGCTGGTCATGAGCAAGCTGGGAGAAG
GAATGCTATTGTTTTATCACCTAAAGAATTCAATAGAAAAACAGGATTTGTAGTTGTTTGTCCGATCACTAATCAGAAGA
AGGGATATCCTTTTGAAGTGGACTTACCAGTTAATGGGATATTCCTTGATAGTGGTGGCAGCCCAATAACAGGGGTAATT
TTAACTGATCAAGTTAAATCATTGGATTGGACAGCCCGTAATATAAAAATATTGAAAAACTACGATCCAAATGATGCACA
AATAAAAGAAATAGATGCAATAATTGATGAATGTCTAGCTAAAATAGCCACATACCTTACATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9370.77 Da        Isoelectric Point: 5.1667

>AT77665 WP_202849473.1 NZ_CP021850:c1302096-1301845 [Pseudoclostridium thermosuccinogenes]
MATVIAQKWGNSLGIRIPKEAAEKVGIKQGSEIELIIAENDEIITLKPKRLQKKYTLEDLLSQITPENRHNEIDFGSEGR
ELI

Download         Length: 252 bp

>AT77665 NZ_CP021850:c1302096-1301845 [Pseudoclostridium thermosuccinogenes]
ATGGCTACAGTCATTGCCCAAAAGTGGGGAAACAGCTTGGGAATACGTATTCCAAAAGAAGCTGCCGAGAAAGTAGGCAT
CAAACAAGGTTCCGAAATTGAATTGATTATTGCTGAAAACGATGAAATCATCACATTAAAACCAAAAAGATTACAAAAGA
AATACACATTAGAAGATCTTTTATCACAAATTACTCCTGAAAACCGACACAATGAAATTGATTTTGGAAGCGAAGGGCGT
GAATTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References