Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 117264..117867 Replicon chromosome
Accession NZ_CP021848
Organism Thermococcus sp. 5-4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDI07_RS00660 Protein ID WP_088179776.1
Coordinates 117475..117867 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDI07_RS00655 Protein ID WP_088179775.1
Coordinates 117264..117488 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDI07_RS00640 (CDI07_00640) 112366..113442 + 1077 WP_088179772.1 choice-of-anchor L domain-containing protein -
CDI07_RS00645 (CDI07_00645) 113439..114797 - 1359 WP_088179773.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
CDI07_RS00650 (CDI07_00650) 114880..117207 + 2328 WP_088179774.1 DNA polymerase -
CDI07_RS00655 (CDI07_00655) 117264..117488 + 225 WP_088179775.1 hypothetical protein Antitoxin
CDI07_RS00660 (CDI07_00660) 117475..117867 + 393 WP_088179776.1 type II toxin-antitoxin system VapC family toxin Toxin
CDI07_RS00665 (CDI07_00665) 117864..118565 - 702 WP_088179777.1 HAD family hydrolase -
CDI07_RS00670 (CDI07_00670) 118605..119636 - 1032 WP_088179778.1 DUF3226 domain-containing protein -
CDI07_RS00675 (CDI07_00675) 119637..120176 - 540 WP_226996590.1 DUF2391 family protein -
CDI07_RS00680 (CDI07_00680) 120241..121710 + 1470 WP_088179780.1 S-layer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14613.80 Da        Isoelectric Point: 4.3912

>T77664 WP_088179776.1 NZ_CP021848:117475-117867 [Thermococcus sp. 5-4]
VIVVDASVLVRVLLKEPGWEGIELDSSTATLDYAFVEGMNAIWKAIRRGRATEEAGRNLITVLKLIWEGMLTFEAQNFFE
RGLEIALSENITIYDALYIALAEALNSDFLTADEKQYLAAKNYVNARLLR

Download         Length: 393 bp

>T77664 NZ_CP021848:117475-117867 [Thermococcus sp. 5-4]
GTGATAGTCGTTGATGCCTCGGTTCTCGTCAGGGTTCTCCTCAAGGAACCAGGCTGGGAGGGAATTGAGCTCGATTCCAG
CACGGCGACGCTGGACTATGCCTTCGTTGAAGGAATGAACGCTATATGGAAGGCCATTAGGAGGGGTAGAGCCACCGAAG
AGGCCGGCAGAAACCTTATAACTGTCCTCAAACTCATCTGGGAGGGCATGCTCACGTTTGAGGCGCAAAACTTCTTCGAG
CGGGGGCTGGAAATAGCATTGAGTGAGAACATTACGATCTACGACGCCCTTTACATAGCCCTGGCCGAGGCGCTGAACTC
GGATTTTCTGACTGCGGACGAGAAACAGTATCTGGCCGCCAAAAATTATGTAAATGCCAGACTCCTTCGCTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8928.39 Da        Isoelectric Point: 10.2394

>AT77664 WP_088179775.1 NZ_CP021848:117264-117488 [Thermococcus sp. 5-4]
MAIVTVRVPDELKLKMKELDINWSEEIREFIRRRIDEEERRKKIKEAMEILKRTPVSVEKGFAAKSVREDRDSR

Download         Length: 225 bp

>AT77664 NZ_CP021848:117264-117488 [Thermococcus sp. 5-4]
ATGGCCATCGTTACTGTCCGCGTTCCCGATGAGTTGAAGCTTAAGATGAAGGAGCTTGACATAAACTGGAGCGAGGAGAT
TAGAGAGTTCATAAGAAGACGCATAGACGAGGAAGAACGGAGAAAGAAGATAAAAGAGGCCATGGAGATACTCAAACGCA
CGCCGGTTTCTGTTGAGAAGGGGTTTGCAGCGAAGTCAGTGAGGGAGGACCGTGATAGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References