Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4683312..4683809 Replicon chromosome
Accession NZ_CP021844
Organism Escherichia coli strain EC1515

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag CDH89_RS23665 Protein ID WP_001173343.1
Coordinates 4683312..4683485 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag CDH89_RS23670 Protein ID WP_000398619.1
Coordinates 4683513..4683809 (-) Length 99 a.a.

Genomic Context


CDH89_RS23655CDH89_RS23660CDH89_RS23690CDH89_RS23695CDH89_RS23665CDH89_RS23670CDH89_RS23680CDH89_RS23685
Location: 4679982..4681439 (1458 bp)
Type: Others
Protein ID: WP_000856835.1
Location: 4681676..4683193 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Location: 4684731..4686362 (1632 bp)
Type: Others
Protein ID: WP_001216477.1
Location: 4686359..4687078 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Location: 4683312..4683485 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Location: 4683513..4683809 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 4684036..4684308 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Location: 4684320..4684550 (231 bp)
Type: Others
Protein ID: WP_000371704.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CDH89_RS236554679982..4681439+1458WP_000856835.1dipeptide/tripeptide permease DtpC-
CDH89_RS236604681676..4683193+1518WP_001295074.1lysine--tRNA ligase-
CDH89_RS236654683312..4683485-174WP_001173343.1type V toxin-antitoxin system toxin GhoTToxin
CDH89_RS236704683513..4683809-297WP_000398619.1type V toxin-antitoxin system endoribonuclease antitoxin GhoSAntitoxin
CDH89_RS236804684036..4684308-273WP_000405647.1N-acetyltransferase-
CDH89_RS236854684320..4684550-231WP_000371704.1(4Fe-4S)-binding protein-
CDH89_RS236904684731..4686362+1632WP_001216477.1sensor histidine kinase-
CDH89_RS236954686359..4687078+720WP_000611288.1two-component system response regulator DcuR-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--4641448..468380942361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-57)

Antitoxin

(5-94)


Sequences


Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T77649 WP_001173343.1 NZ_CP021844:c4683485-4683312 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T77649 NZ_CP021844:c4683485-4683312 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT77649 WP_000398619.1 NZ_CP021844:c4683809-4683513 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT77649 NZ_CP021844:c4683809-4683513 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9QI41


Antitoxin

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Source
ID
Structure
PDB2LLZ
AlphaFold DBA0A7U9QBH6

References