Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | V | Classification (family/domain) | ghoTS/ghoT-GhoS |
Location | 4683312..4683809 | Replicon | chromosome |
Accession | NZ_CP021844 | ||
Organism | Escherichia coli strain EC1515 |
Toxin (Protein)
Gene name | ghoT | Uniprot ID | L4JJG6 |
Locus tag | CDH89_RS23665 | Protein ID | WP_001173343.1 |
Coordinates | 4683312..4683485 (-) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | ghoS | Uniprot ID | L4JK92 |
Locus tag | CDH89_RS23670 | Protein ID | WP_000398619.1 |
Coordinates | 4683513..4683809 (-) | Length | 99 a.a. |
Genomic Context
Location: 4679982..4681439 (1458 bp)
Type: Others
Protein ID: WP_000856835.1
Type: Others
Protein ID: WP_000856835.1
Location: 4681676..4683193 (1518 bp)
Type: Others
Protein ID: WP_001295074.1
Type: Others
Protein ID: WP_001295074.1
Location: 4684731..4686362 (1632 bp)
Type: Others
Protein ID: WP_001216477.1
Type: Others
Protein ID: WP_001216477.1
Location: 4686359..4687078 (720 bp)
Type: Others
Protein ID: WP_000611288.1
Type: Others
Protein ID: WP_000611288.1
Location: 4683312..4683485 (174 bp)
Type: Toxin
Protein ID: WP_001173343.1
Type: Toxin
Protein ID: WP_001173343.1
Location: 4683513..4683809 (297 bp)
Type: Antitoxin
Protein ID: WP_000398619.1
Type: Antitoxin
Protein ID: WP_000398619.1
Location: 4684036..4684308 (273 bp)
Type: Others
Protein ID: WP_000405647.1
Type: Others
Protein ID: WP_000405647.1
Location: 4684320..4684550 (231 bp)
Type: Others
Protein ID: WP_000371704.1
Type: Others
Protein ID: WP_000371704.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDH89_RS23655 | 4679982..4681439 | + | 1458 | WP_000856835.1 | dipeptide/tripeptide permease DtpC | - |
CDH89_RS23660 | 4681676..4683193 | + | 1518 | WP_001295074.1 | lysine--tRNA ligase | - |
CDH89_RS23665 | 4683312..4683485 | - | 174 | WP_001173343.1 | type V toxin-antitoxin system toxin GhoT | Toxin |
CDH89_RS23670 | 4683513..4683809 | - | 297 | WP_000398619.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | Antitoxin |
CDH89_RS23680 | 4684036..4684308 | - | 273 | WP_000405647.1 | N-acetyltransferase | - |
CDH89_RS23685 | 4684320..4684550 | - | 231 | WP_000371704.1 | (4Fe-4S)-binding protein | - |
CDH89_RS23690 | 4684731..4686362 | + | 1632 | WP_001216477.1 | sensor histidine kinase | - |
CDH89_RS23695 | 4686359..4687078 | + | 720 | WP_000611288.1 | two-component system response regulator DcuR | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 4641448..4683809 | 42361 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6555.06 Da Isoelectric Point: 10.2288
>T77649 WP_001173343.1 NZ_CP021844:c4683485-4683312 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF
Download Length: 174 bp
>T77649 NZ_CP021844:c4683485-4683312 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 99 a.a. Molecular weight: 11467.97 Da Isoelectric Point: 4.1705
>AT77649 WP_000398619.1 NZ_CP021844:c4683809-4683513 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK
Download Length: 297 bp
>AT77649 NZ_CP021844:c4683809-4683513 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAATAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAATAG
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QI41 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
PDB | 2LLZ | |
AlphaFold DB | A0A7U9QBH6 |