Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4670712..4671547 Replicon chromosome
Accession NZ_CP021844
Organism Escherichia coli strain EC1515

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5F1UHJ9
Locus tag CDH89_RS23605 Protein ID WP_039023548.1
Coordinates 4671170..4671547 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag CDH89_RS23600 Protein ID WP_001285607.1
Coordinates 4670712..4671080 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDH89_RS23565 4666604..4667284 + 681 WP_001282919.1 WYL domain-containing protein -
CDH89_RS23570 4667432..4668109 + 678 WP_001097301.1 hypothetical protein -
CDH89_RS23575 4668139..4668348 + 210 WP_032150870.1 DUF905 family protein -
CDH89_RS23580 4668438..4669256 + 819 WP_001175175.1 DUF945 domain-containing protein -
CDH89_RS23585 4669348..4669833 + 486 WP_000213722.1 antirestriction protein -
CDH89_RS23590 4669848..4670324 + 477 WP_001384029.1 RadC family protein -
CDH89_RS23595 4670411..4670632 + 222 WP_000692350.1 DUF987 domain-containing protein -
CDH89_RS23600 4670712..4671080 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CDH89_RS23605 4671170..4671547 + 378 WP_039023548.1 TA system toxin CbtA family protein Toxin
CDH89_RS28360 4671544..4671714 + 171 Protein_4353 hypothetical protein -
CDH89_RS23610 4671769..4671966 + 198 WP_088172489.1 DUF957 domain-containing protein -
CDH89_RS23615 4672051..4672917 + 867 WP_039023551.1 DUF4942 domain-containing protein -
CDH89_RS23620 4672989..4673252 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
CDH89_RS23625 4673249..4673575 + 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
CDH89_RS23635 4674458..4675996 + 1539 WP_088172268.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4641448..4683809 42361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14088.99 Da        Isoelectric Point: 7.3523

>T77648 WP_039023548.1 NZ_CP021844:4671170-4671547 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T77648 NZ_CP021844:4671170-4671547 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT77648 WP_001285607.1 NZ_CP021844:4670712-4671080 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT77648 NZ_CP021844:4670712-4671080 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1UHJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References