Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 956221..956875 Replicon chromosome
Accession NZ_CP021844
Organism Escherichia coli strain EC1515

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag CDH89_RS04815 Protein ID WP_000244777.1
Coordinates 956468..956875 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7B3IGV2
Locus tag CDH89_RS04810 Protein ID WP_021577895.1
Coordinates 956221..956487 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDH89_RS04790 952309..953742 - 1434 WP_021577897.1 6-phospho-beta-glucosidase BglA -
CDH89_RS04795 953787..954098 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
CDH89_RS04800 954262..954921 + 660 WP_000250270.1 hemolysin III family protein -
CDH89_RS04805 954998..955978 - 981 WP_021577896.1 tRNA-modifying protein YgfZ -
CDH89_RS04810 956221..956487 + 267 WP_021577895.1 FAD assembly factor SdhE Antitoxin
CDH89_RS04815 956468..956875 + 408 WP_000244777.1 toxin CptA Toxin
CDH89_RS04820 956915..957436 - 522 WP_001055874.1 flavodoxin FldB -
CDH89_RS04825 957548..958444 + 897 WP_000806630.1 site-specific tyrosine recombinase XerD -
CDH89_RS04830 958469..959179 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CDH89_RS04835 959185..960918 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T77629 WP_000244777.1 NZ_CP021844:956468-956875 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T77629 NZ_CP021844:956468-956875 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10616.23 Da        Isoelectric Point: 5.6483

>AT77629 WP_021577895.1 NZ_CP021844:956221-956487 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDRLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT77629 NZ_CP021844:956221-956487 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGATTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTTGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7B3IGV2

References