Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2159502..2160138 Replicon chromosome
Accession NZ_CP021838
Organism Anoxybacillus flavithermus strain 52-1A

Toxin (Protein)


Gene name mazF Uniprot ID A0A178T3V4
Locus tag CA592_RS11610 Protein ID WP_004888744.1
Coordinates 2159788..2160138 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID M8DWL2
Locus tag CA592_RS11605 Protein ID WP_003398486.1
Coordinates 2159502..2159783 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA592_RS11585 2155069..2155431 + 363 WP_004888740.1 holo-ACP synthase -
CA592_RS11590 2155506..2156525 + 1020 WP_004888741.1 outer membrane lipoprotein carrier protein LolA -
CA592_RS11595 2156619..2157791 + 1173 WP_088223580.1 alanine racemase -
CA592_RS11600 2157997..2159277 + 1281 WP_088223581.1 HNH endonuclease -
CA592_RS11605 2159502..2159783 + 282 WP_003398486.1 hypothetical protein Antitoxin
CA592_RS11610 2159788..2160138 + 351 WP_004888744.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CA592_RS11615 2160160..2162361 + 2202 WP_004888745.1 RNA-binding transcriptional accessory protein -
CA592_RS11620 2162356..2162469 - 114 WP_012573928.1 cortex morphogenetic protein CmpA -
CA592_RS11625 2162542..2162997 + 456 WP_004888746.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.02 Da        Isoelectric Point: 4.8781

>T77586 WP_004888744.1 NZ_CP021838:2159788-2160138 [Anoxybacillus flavithermus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDARRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T77586 NZ_CP021838:2159788-2160138 [Anoxybacillus flavithermus]
TTGATTGTCAAACGTGGTGACGTGTATTTTGCCGATCTTTCTCCAGTAGTTGGATCAGAGCAAGGGGGCGTGCGCCCTGT
GCTTGTTATTCAAAATGACATCGGGAACCGTTTTAGTCCAACCGTCATCGTTGCTGCCATTACTGCGCAAATCCAAAAAG
CGAAGTTGCCTACACATGTTGAAATCGACGCAAGGCGCTACGGATTTGAACGGGACTCTGTCATTTTACTTGAACAAATT
CGGACGATTGATAAACAACGTCTGACAGATAAGATTACCCATCTAGATGATGAGATGATGGATAAAGTAGATGAAGCGTT
GCAAATTAGTCTCGGTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10606.17 Da        Isoelectric Point: 7.0147

>AT77586 WP_003398486.1 NZ_CP021838:2159502-2159783 [Anoxybacillus flavithermus]
VSESSATTEIVIRLPQALVSELDGIVKQENGSRNELIYQAMKMYIRERKKRQIREAMRRGYMEMAKINLSLASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT77586 NZ_CP021838:2159502-2159783 [Anoxybacillus flavithermus]
GTGTCTGAATCCAGCGCAACAACAGAAATTGTTATTCGGTTACCACAGGCGTTAGTGAGCGAATTAGATGGAATTGTGAA
GCAAGAAAACGGCAGCCGAAATGAACTGATTTATCAAGCGATGAAAATGTACATCCGTGAGCGGAAAAAACGTCAAATTC
GAGAAGCGATGAGACGTGGGTATATGGAGATGGCGAAAATTAATTTGTCGCTTGCGTCGGAAGCTTTTCTTGCGGAATAT
GAAGCTGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178T3V4

Antitoxin

Source ID Structure
AlphaFold DB M8DWL2

References