Detailed information of TA system TA077562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1024356..1025026
• Replicon: plasmid psymA
• Accession: NZ_CP021830
• Organism: Sinorhizobium meliloti strain HM006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CDO22_RS23705
• Protein ID: WP_015242680.1
• Coordinates: 1024356..1024775 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6A7ZM99
• Locus tag: CDO22_RS23710
• Protein ID: WP_015242681.1
• Coordinates: 1024772..1025026 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDO22_RS23685	1019417..1020576	+	1160	Protein_977	GGDEF domain-containing protein	-
CDO22_RS23690	1020633..1020995	-	363	WP_088202399.1	response regulator	-
CDO22_RS23695	1021023..1023557	-	2535	WP_088202400.1	PAS domain S-box protein	-
CDO22_RS23700	1023959..1024387	+	429	WP_153315244.1	GFA family protein	-
CDO22_RS23705	1024356..1024775	-	420	WP_015242680.1	type II toxin-antitoxin system VapC family toxin	Toxin
CDO22_RS23710	1024772..1025026	-	255	WP_015242681.1	plasmid stability protein	Antitoxin
CDO22_RS23715	1025195..1026181	-	987	WP_088202401.1	ATP-binding cassette domain-containing protein	-
CDO22_RS23720	1026178..1027092	-	915	WP_088202402.1	ABC transporter ATP-binding protein	-
CDO22_RS23725	1027089..1027910	-	822	WP_010967053.1	ABC transporter permease	-
CDO22_RS23730	1027916..1028851	-	936	WP_027989450.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	htpB	1..1484605	1484605

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14761.01 Da
• Isoelectric Point: 6.7266

>T77562 WP_015242680.1 NZ_CP021830:c1024775-1024356 [Sinorhizobium meliloti]
MIVLGTNVVSEAMKPTPDPAVRSWLNEQVAETLYLASVTLAELLFGIGALPDGRRKKALTEMLGGVLELFGDRVLPFDIG
AARHYAELAVTARAAGKGFPTADGYIAAIAASRGFIVATRDSSPFEAAGLTVVNPWHHR

Nucleotide

• Length: 420 bp

>T77562 NZ_CP021830:c1024775-1024356 [Sinorhizobium meliloti]
ATGATTGTCCTCGGTACGAATGTCGTCTCCGAGGCGATGAAACCGACCCCCGATCCGGCCGTGCGCTCCTGGTTGAACGA
GCAGGTCGCTGAAACCTTGTATCTGGCCAGTGTGACCTTGGCCGAACTGCTGTTCGGCATCGGTGCGCTGCCGGACGGCC
GGCGCAAGAAGGCTCTGACCGAAATGCTTGGCGGCGTGCTCGAACTGTTTGGCGATCGCGTATTGCCGTTCGACATCGGA
GCTGCTCGCCATTATGCCGAGCTTGCGGTGACCGCTCGAGCGGCCGGCAAGGGATTTCCGACGGCCGACGGATATATTGC
CGCCATTGCCGCCTCCAGGGGATTTATCGTCGCGACCCGCGATAGCAGCCCGTTCGAAGCGGCTGGACTTACCGTGGTAA
ATCCTTGGCACCATCGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9480.82 Da
• Isoelectric Point: 6.4732

>AT77562 WP_015242681.1 NZ_CP021830:c1025026-1024772 [Sinorhizobium meliloti]
MAILTVRNVPDEVHRALRVRAAMHGRSTEAEVREILESAVKPEQRVRMGDALAELGRRLGLTNDDFAVFDEVRDKAPAQP
VRFE

Nucleotide

• Length: 255 bp

>AT77562 NZ_CP021830:c1025026-1024772 [Sinorhizobium meliloti]
ATGGCGATCCTGACGGTCCGGAATGTGCCCGATGAAGTGCATCGCGCCTTGCGCGTGAGAGCGGCGATGCACGGCCGCAG
CACCGAGGCGGAAGTCCGGGAGATTTTGGAAAGTGCGGTGAAGCCCGAGCAGCGCGTTCGCATGGGCGATGCCCTGGCCG
AGCTCGGCCGGCGACTGGGGCTGACCAACGACGATTTCGCCGTGTTCGACGAGGTACGCGACAAGGCGCCGGCGCAGCCC
GTGAGATTTGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A6A7ZM99