77561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 913437..914017 Replicon plasmid psymA
Accession NZ_CP021830
Organism Sinorhizobium meliloti strain HM006

Toxin (Protein)


Gene name vapC Uniprot ID Q92XP1
Locus tag CDO22_RS23115 Protein ID WP_010968151.1
Coordinates 913634..914017 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F7XCL0
Locus tag CDO22_RS23110 Protein ID WP_013851145.1
Coordinates 913437..913637 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO22_RS23095 909746..910600 - 855 WP_088202350.1 hydrolase -
CDO22_RS23100 910659..912233 - 1575 WP_088202351.1 ABC transporter substrate-binding protein -
CDO22_RS23105 912422..913189 + 768 WP_088202352.1 IclR family transcriptional regulator -
CDO22_RS23110 913437..913637 + 201 WP_013851145.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CDO22_RS23115 913634..914017 + 384 WP_010968151.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO22_RS23120 914466..914861 + 396 WP_088195962.1 response regulator -
CDO22_RS23130 915782..916618 + 837 WP_015242582.1 TIGR02587 family membrane protein -
CDO22_RS23135 916615..917061 + 447 WP_017264491.1 TIGR02588 family protein -
CDO22_RS35975 917334..917965 + 632 Protein_874 DUF433 domain-containing protein -
CDO22_RS23150 917962..918201 + 240 WP_080659497.1 DUF5615 family PIN-like protein -
CDO22_RS23160 918565..918969 - 405 WP_017264489.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1484605 1484605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14292.54 Da        Isoelectric Point: 6.9172

>T77561 WP_010968151.1 NZ_CP021830:913634-914017 [Sinorhizobium meliloti]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

>T77561 NZ_CP021830:913634-914017 [Sinorhizobium meliloti]
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTATTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTTGGCAGCCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCAGGAGGTCATGATGATGATCGATCGCCACGCCATTTTTAGCATG
GGGATTGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTCCTCGATCAGCGAATGGCTTTGTGGACGAGAGACAAGCG
TTTGCAGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACGCGGAACTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7096.22 Da        Isoelectric Point: 11.1107

>AT77561 WP_013851145.1 NZ_CP021830:913437-913637 [Sinorhizobium meliloti]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK

Download         Length: 201 bp

>AT77561 NZ_CP021830:913437-913637 [Sinorhizobium meliloti]
ATGCGATCGACTATCAACCTCGACGACACTCTCATGGAAAGGGCTAAGTCCCTAACCGGCACAAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAAGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92XP1

Antitoxin

Source ID Structure
AlphaFold DB A0A7W6MID2

References