Detailed information of TA system TA077552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1313965..1314605
• Replicon: chromosome
• Accession: NZ_CP021829
• Organism: Sinorhizobium meliloti strain HM006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H0G6N1
• Locus tag: CDO22_RS06190
• Protein ID: WP_003533691.1
• Coordinates: 1313965..1314351 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H0G6N0
• Locus tag: CDO22_RS06195
• Protein ID: WP_003533689.1
• Coordinates: 1314351..1314605 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDO22_RS06165	1309429..1309908	+	480	WP_003537307.1	GNAT family N-acetyltransferase	-
CDO22_RS06170	1309952..1310401	-	450	WP_003537305.1	nucleoside deaminase	-
CDO22_RS06175	1310476..1312197	+	1722	WP_010968830.1	pseudouridine synthase	-
CDO22_RS06180	1312204..1312764	+	561	WP_010968831.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
CDO22_RS06185	1312837..1313736	+	900	WP_010968832.1	patatin-like phospholipase family protein	-
CDO22_RS06190	1313965..1314351	-	387	WP_003533691.1	type II toxin-antitoxin system VapC family toxin	Toxin
CDO22_RS06195	1314351..1314605	-	255	WP_003533689.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CDO22_RS06200	1314744..1316576	-	1833	WP_010968833.1	monovalent cation:proton antiporter-2 (CPA2) family protein	-
CDO22_RS06205	1316728..1318074	+	1347	WP_010968834.1	TldD/PmbA family protein	-
CDO22_RS06210	1318183..1319001	+	819	WP_010968835.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
CDO22_RS06215	1319062..1319298	+	237	WP_003533684.1	DUF4170 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13904.77 Da
• Isoelectric Point: 4.5716

>T77552 WP_003533691.1 NZ_CP021829:c1314351-1313965 [Sinorhizobium meliloti]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIETRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Nucleotide

• Length: 387 bp

>T77552 NZ_CP021829:c1314351-1313965 [Sinorhizobium meliloti]
ATGGTCATCGACACATCCGCCATTGCCGCGATTGCCTTCAATGAACAGGAGGCCGGAAGTTTCCGCGAAAAAATCGCGGA
CGACCCGGTTCGGCTCATCTCCGCGGCAACCGCTCTGGAAGCGGCCATGGTAATCGAAACCCGGTTAGGCGAAGCTGCCG
GAGCGGAACTTGATCTTTGGCTTTACAAGGCAAACGTGGAGATTGTTGCGGTAACCGCCGAGCATATGGACCAGGCCCGC
CGTGCCTGGCGCCGTTTCGGCAAAGGCCGTCATCCGGCCGGTTTGAATTTCGGTGATTGTTTTTCCTATGCCCTGGCCTT
TCTGACAAATGAACCGCTTCTCTTCAAGGGAAGCGATTTCTCGCAAACCGATATCCCGGCGGCATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9472.63 Da
• Isoelectric Point: 4.8660

>AT77552 WP_003533689.1 NZ_CP021829:c1314605-1314351 [Sinorhizobium meliloti]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Nucleotide

• Length: 255 bp

>AT77552 NZ_CP021829:c1314605-1314351 [Sinorhizobium meliloti]
ATGGCGCTGAGCATCAAGGACACTGAAACCGAGCAGCTTGCCCGCACACTTGCCCGGCGGACAGGGGAATCCATCACGCT
TGCCACCAAGCGTGCCCTCGAAGAACGATTGCGCCGAACCGACACCGCTGCCCGGCGCGCGGCTCTTCTGGAGGATCTGG
AAGCCATTCAACGCCGCTGGAATGCCATGCCCGTCCTCGACAGTCGCAGCTCCGATGACATTATCGGTTATGACGAGGAT
GGACTCCCCTCATAA

Structures

Toxin

• AlphaFold DB: H0G6N1

Antitoxin

• AlphaFold DB: H0G6N0