Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 116991..117661 Replicon plasmid psymA
Accession NZ_CP021827
Organism Sinorhizobium meliloti strain KH35c

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO23_RS19625 Protein ID WP_088217945.1
Coordinates 116991..117410 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO23_RS19630 Protein ID WP_017264429.1
Coordinates 117407..117661 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO23_RS19600 112050..113210 + 1161 WP_017264434.1 GGDEF domain-containing protein -
CDO23_RS19605 113267..113629 - 363 WP_026030666.1 response regulator -
CDO23_RS19610 113657..116191 - 2535 WP_088217942.1 PAS domain S-box protein -
CDO23_RS19620 116594..117022 + 429 WP_088217944.1 GFA family protein -
CDO23_RS19625 116991..117410 - 420 WP_088217945.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO23_RS19630 117407..117661 - 255 WP_017264429.1 plasmid stabilization protein Antitoxin
CDO23_RS19635 117852..118814 - 963 WP_027989026.1 ATP-binding cassette domain-containing protein -
CDO23_RS19640 118811..119725 - 915 WP_010967054.1 ABC transporter ATP-binding protein -
CDO23_RS19645 119722..120543 - 822 WP_017276072.1 ABC transporter permease -
CDO23_RS19650 120549..121484 - 936 WP_027989450.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1279723 1279723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14644.93 Da        Isoelectric Point: 8.5565

>T77544 WP_088217945.1 NZ_CP021827:c117410-116991 [Sinorhizobium meliloti]
MIVLGTNVVSEAMKPTPDPAVRSWLNEQVAETLYLASVTLAELLFGIGALPDGRRKKALTEMLGGVLELFGDRVLPFDIG
AARHYAELAVTARAAGKGFPTADGYIAAIAASRGFIVATRASSPFGAAGLTVVNPWHHR

Download         Length: 420 bp

>T77544 NZ_CP021827:c117410-116991 [Sinorhizobium meliloti]
ATGATTGTCCTCGGTACGAATGTCGTCTCCGAGGCGATGAAACCGACCCCCGATCCGGCCGTGCGCTCCTGGTTGAACGA
GCAGGTCGCTGAAACCTTGTATCTGGCCAGTGTGACCTTGGCCGAACTGCTGTTCGGCATCGGTGCGCTGCCGGACGGCC
GGCGCAAGAAGGCTCTGACCGAAATGCTTGGCGGCGTGCTCGAACTGTTTGGCGATCGCGTATTGCCGTTCGACATCGGA
GCTGCTCGCCATTATGCCGAGCTTGCGGTGACCGCTCGAGCGGCCGGCAAGGGATTTCCGACGGCCGACGGATATATTGC
CGCCATTGCCGCCTCCAGGGGATTTATCGTCGCGACCCGCGCTAGCAGCCCGTTCGGAGCGGCTGGACTTACCGTGGTAA
ATCCTTGGCACCATCGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9466.79 Da        Isoelectric Point: 6.4732

>AT77544 WP_017264429.1 NZ_CP021827:c117661-117407 [Sinorhizobium meliloti]
MAILTVRNVPDEVHRALRVRAAMHGRSTEAEVREILESAVKPEQRVRMGDALAEVGRRLGLTNDDFAVFDEVRDKAPAQP
VRFE

Download         Length: 255 bp

>AT77544 NZ_CP021827:c117661-117407 [Sinorhizobium meliloti]
ATGGCGATCCTGACGGTCCGGAATGTGCCCGATGAAGTGCATCGCGCCTTGCGCGTGAGAGCGGCGATGCACGGCCGCAG
CACCGAGGCGGAAGTCCGGGAGATTTTGGAAAGTGCGGTGAAGCCCGAGCAGCGTGTTCGCATGGGCGATGCCCTGGCCG
AGGTCGGCCGGCGACTGGGGCTGACCAATGACGATTTCGCCGTGTTCGACGAGGTACGCGACAAGGCGCCGGCGCAGCCC
GTGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References