Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 474871..475370 | Replicon | plasmid psymA |
Accession | NZ_CP021824 | ||
Organism | Sinorhizobium meliloti strain KH46 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q92YA6 |
Locus tag | CDO24_RS29095 | Protein ID | WP_010967939.1 |
Coordinates | 475197..475370 (+) | Length | 58 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A843ZXX9 |
Locus tag | CDO24_RS35555 | Protein ID | WP_014990215.1 |
Coordinates | 474871..475200 (+) | Length | 110 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDO24_RS29055 | 470246..470422 | + | 177 | WP_013845643.1 | hypothetical protein | - |
CDO24_RS29060 | 470548..471441 | - | 894 | WP_010967943.1 | LysR family transcriptional regulator | - |
CDO24_RS29065 | 471533..471976 | + | 444 | WP_010967942.1 | PACE efflux transporter | - |
CDO24_RS29070 | 472093..472431 | + | 339 | WP_013845641.1 | SDR family oxidoreductase | - |
CDO24_RS29075 | 472415..472756 | - | 342 | Protein_474 | hypothetical protein | - |
CDO24_RS29080 | 473140..474510 | - | 1371 | WP_013845640.1 | alpha/beta hydrolase | - |
CDO24_RS29085 | 474751..474936 | - | 186 | WP_013845639.1 | hypothetical protein | - |
CDO24_RS35555 | 474871..475200 | + | 330 | WP_014990215.1 | hypothetical protein | Antitoxin |
CDO24_RS29095 | 475197..475370 | + | 174 | WP_010967939.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CDO24_RS29100 | 475468..475773 | - | 306 | WP_013845638.1 | hypothetical protein | - |
CDO24_RS29110 | 476092..476451 | - | 360 | WP_013845635.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
CDO24_RS29115 | 477046..477297 | + | 252 | WP_003534243.1 | GlsB/YeaQ/YmgE family stress response membrane protein | - |
CDO24_RS29120 | 477325..477810 | + | 486 | WP_010967936.1 | YidB family protein | - |
CDO24_RS29125 | 478189..479505 | - | 1317 | WP_013845634.1 | aspartate aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | htpB | 1..1597380 | 1597380 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 58 a.a. Molecular weight: 6497.32 Da Isoelectric Point: 5.7733
>T77536 WP_010967939.1 NZ_CP021824:475197-475370 [Sinorhizobium meliloti]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP
Download Length: 174 bp
>T77536 NZ_CP021824:475197-475370 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12067.72 Da Isoelectric Point: 11.1401
>AT77536 WP_014990215.1 NZ_CP021824:474871-475200 [Sinorhizobium meliloti]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR
Download Length: 330 bp
>AT77536 NZ_CP021824:474871-475200 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q92YA6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A843ZXX9 |