Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 474871..475370 Replicon plasmid psymA
Accession NZ_CP021824
Organism Sinorhizobium meliloti strain KH46

Toxin (Protein)


Gene name relE Uniprot ID Q92YA6
Locus tag CDO24_RS29095 Protein ID WP_010967939.1
Coordinates 475197..475370 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A843ZXX9
Locus tag CDO24_RS35555 Protein ID WP_014990215.1
Coordinates 474871..475200 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO24_RS29055 470246..470422 + 177 WP_013845643.1 hypothetical protein -
CDO24_RS29060 470548..471441 - 894 WP_010967943.1 LysR family transcriptional regulator -
CDO24_RS29065 471533..471976 + 444 WP_010967942.1 PACE efflux transporter -
CDO24_RS29070 472093..472431 + 339 WP_013845641.1 SDR family oxidoreductase -
CDO24_RS29075 472415..472756 - 342 Protein_474 hypothetical protein -
CDO24_RS29080 473140..474510 - 1371 WP_013845640.1 alpha/beta hydrolase -
CDO24_RS29085 474751..474936 - 186 WP_013845639.1 hypothetical protein -
CDO24_RS35555 474871..475200 + 330 WP_014990215.1 hypothetical protein Antitoxin
CDO24_RS29095 475197..475370 + 174 WP_010967939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO24_RS29100 475468..475773 - 306 WP_013845638.1 hypothetical protein -
CDO24_RS29110 476092..476451 - 360 WP_013845635.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
CDO24_RS29115 477046..477297 + 252 WP_003534243.1 GlsB/YeaQ/YmgE family stress response membrane protein -
CDO24_RS29120 477325..477810 + 486 WP_010967936.1 YidB family protein -
CDO24_RS29125 478189..479505 - 1317 WP_013845634.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1597380 1597380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6497.32 Da        Isoelectric Point: 5.7733

>T77536 WP_010967939.1 NZ_CP021824:475197-475370 [Sinorhizobium meliloti]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Download         Length: 174 bp

>T77536 NZ_CP021824:475197-475370 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12067.72 Da        Isoelectric Point: 11.1401

>AT77536 WP_014990215.1 NZ_CP021824:474871-475200 [Sinorhizobium meliloti]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Download         Length: 330 bp

>AT77536 NZ_CP021824:474871-475200 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92YA6

Antitoxin

Source ID Structure
AlphaFold DB A0A843ZXX9

References