Detailed information of TA system TA077534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 126392..126990
• Replicon: plasmid psymA
• Accession: NZ_CP021824
• Organism: Sinorhizobium meliloti strain KH46

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CDO24_RS27120
• Protein ID: WP_013845238.1
• Coordinates: 126697..126990 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CDO24_RS27115
• Protein ID: WP_014989717.1
• Coordinates: 126392..126700 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDO24_RS27080	121477..123003	+	1527	WP_088200012.1	amidohydrolase	-
CDO24_RS27090	124249..124572	-	324	WP_003526806.1	DNA-binding transcriptional regulator	-
CDO24_RS27095	124562..124916	-	355	Protein_124	type II toxin-antitoxin system RelE/ParE family toxin	-
CDO24_RS35110	125273..126175	+	903	Protein_125	ParB N-terminal domain-containing protein	-
CDO24_RS27115	126392..126700	+	309	WP_014989717.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CDO24_RS27120	126697..126990	+	294	WP_013845238.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CDO24_RS27125	127252..128451	-	1200	WP_164828738.1	NAD-dependent formate dehydrogenase	-
CDO24_RS27130	128845..129617	+	773	Protein_129	ParB N-terminal domain-containing protein	-
CDO24_RS27135	129741..130412	-	672	Protein_130	inositol monophosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	htpB	1..1597380	1597380

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-53)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11202.84 Da
• Isoelectric Point: 6.4735

>T77534 WP_013845238.1 NZ_CP021824:126697-126990 [Sinorhizobium meliloti]
MRLVWARYALDDRDTIFSSIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Nucleotide

• Length: 294 bp

>T77534 NZ_CP021824:126697-126990 [Sinorhizobium meliloti]
ATGAGGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACACCATCTTCAGTTCCATCGAAAGGGAGAATCCGAGGGC
GGCGGTCCACGTCGACGAGGAGATCGTCAGCGCGGTACGTCGTCTGCTTGATTTTCCGGAAAGCGGCCGCCCTGGCCGGA
TTGCCGGAACTCGAGAGCTTGTTATCCCTCGGACCCCCTACATTGCAGCCTACATGGTAATGGAGGATAGAATTCGAATT
CTGCGTGTCCTGCACGGCGCCCAGAAGTGGCCCAGCGAGCTCGACGACGGGTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11228.61 Da
• Isoelectric Point: 5.6604

>AT77534 WP_014989717.1 NZ_CP021824:126392-126700 [Sinorhizobium meliloti]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAAMRKAAAGDR

Nucleotide

• Length: 309 bp

>AT77534 NZ_CP021824:126392-126700 [Sinorhizobium meliloti]
ATGGCTTCAAATGCACTTGTTCAGACTCGAATCGATGCCGAGGTCAAAGAGCGCGCCACGGCGGTTTTAGAGAACATGGG
TCTGACGGTCTCGGACGCTGTTCGAATCCTGTTAACTCGGACGGCGAATGAGGGCGCCCTGCCGCTGGAACTCTTCAGCC
ACAGCGAGGCGCACGACGCTTGGTTCCGCGCCAAAGTGTTGCGGGCACTCGAGGATACCCGACCCGACGTCGACGATGCC
GACGCCGATGCGCACTTTCGAGAGCGCCGGGCGGCAGCTATGCGCAAGGCTGCGGCGGGTGATCGATGA