77527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2822670..2823324 Replicon chromosome
Accession NZ_CP021822
Organism Sinorhizobium meliloti strain KH46

Toxin (Protein)


Gene name hicA Uniprot ID H0G1A3
Locus tag CDO24_RS13755 Protein ID WP_003530010.1
Coordinates 2822670..2822858 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q92NX0
Locus tag CDO24_RS13760 Protein ID WP_010969659.1
Coordinates 2822863..2823324 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO24_RS13740 2819236..2820546 + 1311 WP_010969656.1 HlyD family type I secretion periplasmic adaptor subunit -
CDO24_RS13745 2820571..2821542 - 972 WP_164856611.1 glycosyltransferase family 2 protein -
CDO24_RS13750 2821723..2822493 - 771 WP_010969658.1 hypothetical protein -
CDO24_RS13755 2822670..2822858 + 189 WP_003530010.1 type II toxin-antitoxin system HicA family toxin Toxin
CDO24_RS13760 2822863..2823324 + 462 WP_010969659.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CDO24_RS13765 2823747..2825150 + 1404 WP_088199392.1 tyrosine-type recombinase/integrase -
CDO24_RS35310 2825215..2826708 - 1494 WP_127750046.1 hypothetical protein -
CDO24_RS13785 2826705..2827214 - 510 WP_127750044.1 hypothetical protein -
CDO24_RS13790 2827214..2827702 - 489 WP_088199397.1 hypothetical protein -
CDO24_RS13795 2827695..2828000 - 306 WP_088199398.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6971.15 Da        Isoelectric Point: 11.0889

>T77527 WP_003530010.1 NZ_CP021822:2822670-2822858 [Sinorhizobium meliloti]
MKSGDIIAALQKDGWYEVATKGSHVQFKHPKKHGRVTVPHPKRDLPIGTLRSIEKQSGLKLR

Download         Length: 189 bp

>T77527 NZ_CP021822:2822670-2822858 [Sinorhizobium meliloti]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16293.17 Da        Isoelectric Point: 4.3990

>AT77527 WP_010969659.1 NZ_CP021822:2822863-2823324 [Sinorhizobium meliloti]
MRNYIGLIHKDAESDYGVSFPDFSGVVTAGADLDDARAMAEEALALHIEGLVEDGEAIPEPSSLEVVMSDAENRDCVAIL
VAVKTEAKRAIRVNVTLPEGVLKQIDAFAEAHGLTRSGFLARAATHEIERANDGHDAYAESRLSALGTSSKNV

Download         Length: 462 bp

>AT77527 NZ_CP021822:2822863-2823324 [Sinorhizobium meliloti]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H0G1A3

Antitoxin

Source ID Structure
AlphaFold DB Q92NX0

References