Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 332521..333056 Replicon plasmid accessoryA
Accession NZ_CP021821
Organism Sinorhizobium meliloti strain M162

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CDO25_RS33555 Protein ID WP_088201691.1
Coordinates 332521..332796 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CDO25_RS33560 Protein ID WP_088197958.1
Coordinates 332796..333056 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO25_RS33525 327722..329176 + 1455 WP_088201688.1 FAD-binding oxidoreductase -
CDO25_RS33530 329173..330786 + 1614 WP_088201690.1 GMC family oxidoreductase N-terminal domain-containing protein -
CDO25_RS33535 330928..331134 - 207 Protein_314 FAD-binding oxidoreductase -
CDO25_RS34710 331075..331374 + 300 WP_153416893.1 hypothetical protein -
CDO25_RS33555 332521..332796 - 276 WP_088201691.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO25_RS33560 332796..333056 - 261 WP_088197958.1 ribbon-helix-helix domain-containing protein Antitoxin
CDO25_RS33565 333228..333454 + 227 Protein_318 transposase -
CDO25_RS33575 334511..335539 - 1029 WP_088201692.1 LLM class flavin-dependent oxidoreductase -
CDO25_RS33580 335966..337081 - 1116 WP_088197961.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..416269 416269


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10867.49 Da        Isoelectric Point: 10.8743

>T77521 WP_088201691.1 NZ_CP021821:c332796-332521 [Sinorhizobium meliloti]
MKLEWTRKAVSDLGRLHDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFEPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTRESR

Download         Length: 276 bp

>T77521 NZ_CP021821:c332796-332521 [Sinorhizobium meliloti]
ATGAAGCTCGAGTGGACGCGTAAGGCAGTCTCCGATCTAGGGCGCCTGCATGATTTCCTGGCACCGGTAAATCGGCAAGC
TGCTGCTCGCACTGTGCAATCGTTGACAAGCGCTCCTGCGCGCCTGCTCGAACAACCGCGCATCGGCGAACGGCTGGAGG
AATTCGAGCCACGAGAGGTTCGGCGAATTCTCGTTGGCCATTACGAAATACGGTATGAGATTCGGCAGTCGACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAATCACGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9685.09 Da        Isoelectric Point: 5.1200

>AT77521 WP_088197958.1 NZ_CP021821:c333056-332796 [Sinorhizobium meliloti]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIEHHAVQAWADSLDSDK
PLPLPL

Download         Length: 261 bp

>AT77521 NZ_CP021821:c333056-332796 [Sinorhizobium meliloti]
ATGGAAACCAAGGTGCTGACCGCGCACGTGCCACTGCCACTCGCCGAGAAAGTCGATCAGATCGCCGCCCGCCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGCGTGATCGAGCACCATGCCGTTCAGGCCTGGGCCGACAGTCTTGACAGCGACAAG
CCGCTACCCTTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References