Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 22423..23054 Replicon plasmid accessoryC
Accession NZ_CP021817
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO26_RS36790 Protein ID WP_088199160.1
Coordinates 22668..23054 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO26_RS36785 Protein ID WP_088199159.1
Coordinates 22423..22671 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS40645 17441..17695 + 255 WP_280641142.1 hypothetical protein -
CDO26_RS36755 (CDO26_36755) 17926..18976 + 1051 Protein_17 group II intron reverse transcriptase/maturase -
CDO26_RS36765 (CDO26_36765) 19025..20228 + 1204 Protein_18 IS256-like element ISRm3 family transposase -
CDO26_RS40650 20908..21072 - 165 WP_280641148.1 hypothetical protein -
CDO26_RS36780 (CDO26_36780) 21250..22275 + 1026 Protein_20 tyrosine-type recombinase/integrase -
CDO26_RS36785 (CDO26_36785) 22423..22671 + 249 WP_088199159.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CDO26_RS36790 (CDO26_36790) 22668..23054 + 387 WP_088199160.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO26_RS36795 (CDO26_36795) 23057..23372 + 316 Protein_23 integrase -
CDO26_RS36800 (CDO26_36800) 23415..24337 - 923 Protein_24 IS5 family transposase -
CDO26_RS36805 (CDO26_36805) 24468..25829 - 1362 Protein_25 conjugal transfer protein TrbE -
CDO26_RS36810 (CDO26_36810) 25838..26136 - 299 Protein_26 conjugal transfer protein TrbD -
CDO26_RS36815 (CDO26_36815) 26129..26533 - 405 WP_088199161.1 conjugal transfer pilin TrbC -
CDO26_RS36820 (CDO26_36820) 26523..27488 - 966 WP_088199162.1 P-type conjugative transfer ATPase TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..127177 127177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13982.86 Da        Isoelectric Point: 4.6983

>T77507 WP_088199160.1 NZ_CP021817:22668-23054 [Sinorhizobium meliloti]
VIVDTSALVAILYREPEAASFVNYIHDAETTRISVANYVELSMVVESQLGPDGMRQAEAFFRRAGIIVEPVTLEHGELAR
QAFLDFGKGRHKAGLNFGDCFAYALAKASGEPLLFKGNDFSQTDVLTV

Download         Length: 387 bp

>T77507 NZ_CP021817:22668-23054 [Sinorhizobium meliloti]
GTGATTGTCGACACCTCCGCGCTGGTCGCCATCCTTTACCGCGAGCCCGAAGCGGCAAGCTTTGTCAACTATATCCACGA
CGCCGAAACCACTCGGATCAGCGTCGCCAACTATGTCGAGTTGTCCATGGTGGTGGAAAGCCAGCTCGGACCTGACGGTA
TGCGCCAGGCCGAAGCCTTCTTCCGGCGGGCCGGCATCATCGTTGAGCCGGTCACACTTGAACATGGCGAACTGGCGCGT
CAGGCTTTTCTCGACTTCGGCAAGGGGCGGCACAAGGCCGGTCTTAATTTTGGCGATTGCTTCGCCTACGCCCTCGCCAA
AGCGTCTGGCGAACCGTTACTGTTCAAGGGCAATGACTTCTCTCAAACTGATGTCCTGACGGTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9130.27 Da        Isoelectric Point: 6.9893

>AT77507 WP_088199159.1 NZ_CP021817:22423-22671 [Sinorhizobium meliloti]
VSLSIKDPEAHRLAQAISHATGESMTRVVTNALRERLAKIERQKGRASVEELLAIADRAATHVKHPYDDHADFLYDENGI
PK

Download         Length: 249 bp

>AT77507 NZ_CP021817:22423-22671 [Sinorhizobium meliloti]
GTGAGCCTCAGCATCAAGGATCCAGAAGCCCATCGTCTGGCGCAGGCGATTTCCCACGCGACGGGGGAAAGCATGACCCG
CGTCGTCACCAATGCACTGCGCGAGCGCCTTGCCAAGATCGAACGCCAAAAGGGCCGCGCCAGCGTTGAGGAACTGCTGG
CGATCGCCGACCGTGCCGCAACGCACGTGAAACACCCTTATGACGATCATGCCGACTTTCTTTATGACGAGAACGGCATT
CCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References