Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-Xre |
| Location | 876952..877884 | Replicon | plasmid psymB |
| Accession | NZ_CP021814 | ||
| Organism | Sinorhizobium meliloti strain M270 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q92VJ4 |
| Locus tag | CDO26_RS29890 | Protein ID | WP_010975576.1 |
| Coordinates | 876952..877506 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | H0G7T7 |
| Locus tag | CDO26_RS29895 | Protein ID | WP_003534594.1 |
| Coordinates | 877513..877884 (-) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CDO26_RS29870 (CDO26_29860) | 872484..873350 | + | 867 | WP_010975580.1 | sulfate ABC transporter permease subunit CysT | - |
| CDO26_RS29875 (CDO26_29865) | 873340..874215 | + | 876 | WP_014527285.1 | sulfate ABC transporter permease subunit CysW | - |
| CDO26_RS29880 (CDO26_29870) | 874231..875334 | + | 1104 | WP_010975578.1 | sulfate/molybdate ABC transporter ATP-binding protein | - |
| CDO26_RS29885 (CDO26_29875) | 875446..876816 | + | 1371 | WP_015008367.1 | FAD-binding oxidoreductase | - |
| CDO26_RS29890 (CDO26_29880) | 876952..877506 | - | 555 | WP_010975576.1 | RES family NAD+ phosphorylase | Toxin |
| CDO26_RS29895 (CDO26_29885) | 877513..877884 | - | 372 | WP_003534594.1 | DUF2384 domain-containing protein | Antitoxin |
| CDO26_RS29900 (CDO26_29890) | 877961..878746 | - | 786 | WP_088198602.1 | crotonase/enoyl-CoA hydratase family protein | - |
| CDO26_RS29905 (CDO26_29895) | 878743..879612 | - | 870 | WP_003534602.1 | hydroxymethylglutaryl-CoA lyase | - |
| CDO26_RS29910 (CDO26_29900) | 879609..881597 | - | 1989 | WP_015243150.1 | acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha | - |
| CDO26_RS29915 (CDO26_29905) | 881614..881997 | - | 384 | WP_010975573.1 | RidA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | htpB | 1..1694441 | 1694441 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20459.35 Da Isoelectric Point: 6.4901
>T77505 WP_010975576.1 NZ_CP021814:c877506-876952 [Sinorhizobium meliloti]
MRKHIPPASRPDPEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
MRKHIPPASRPDPEPTSPVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGMPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGARLADLTDASVLLELGVDEAIHRCEWRDALDKGAVPETHRLQSELLARDYHGVIYPSFMSPGGTCVALWRWN
GAEEPRLDVIDPDGRLPKSPASWV
Download Length: 555 bp
>T77505 NZ_CP021814:c877506-876952 [Sinorhizobium meliloti]
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATCCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTGCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA
ATGAGGAAACACATTCCGCCCGCATCGCGACCCGATCCGGAACCGACGTCGCCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCGCGCTGGGCACATATGCCGCTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAACCCGATCGGCA
TGCCTGCGATTTATGCTGCGCGCGAGCTTTCCACTGCCTGGGCTGAATATAATCAGGGTTTCGTGCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAGGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTGCAGTCGGAGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGCGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTGCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA
Antitoxin
Download Length: 124 a.a. Molecular weight: 13113.26 Da Isoelectric Point: 9.9996
>AT77505 WP_003534594.1 NZ_CP021814:c877884-877513 [Sinorhizobium meliloti]
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA
Download Length: 372 bp
>AT77505 NZ_CP021814:c877884-877513 [Sinorhizobium meliloti]
ATGATGGCCGTTGATTTCCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
ATGATGGCCGTTGATTTCCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAATCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCCGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCCGGCAAGACGGCGTTCGATCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|