Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1315743..1316350 Replicon plasmid psymA
Accession NZ_CP021813
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CDO26_RS24975 Protein ID WP_088198315.1
Coordinates 1315743..1315997 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CDO26_RS24980 Protein ID WP_088198316.1
Coordinates 1315994..1316350 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS24950 (CDO26_24960) 1311281..1312012 - 732 WP_088198312.1 HupE/UreJ family protein -
CDO26_RS24955 (CDO26_24965) 1312059..1312478 - 420 WP_234843665.1 hypothetical protein -
CDO26_RS24960 (CDO26_24970) 1312608..1313429 + 822 WP_088198313.1 sulfurtransferase/chromate resistance protein -
CDO26_RS24965 (CDO26_24975) 1313430..1314838 + 1409 Protein_1335 chromate efflux transporter -
CDO26_RS24970 (CDO26_24980) 1314906..1315388 + 483 WP_088198314.1 isoprenylcysteine carboxylmethyltransferase family protein -
CDO26_RS24975 (CDO26_24985) 1315743..1315997 + 255 WP_088198315.1 type II toxin-antitoxin system HicA family toxin Toxin
CDO26_RS24980 (CDO26_24990) 1315994..1316350 + 357 WP_088198316.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CDO26_RS24985 (CDO26_24995) 1316561..1319695 - 3135 WP_088198317.1 multidrug efflux RND transporter permease subunit -
CDO26_RS24990 (CDO26_25000) 1319692..1320858 - 1167 WP_014531439.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1454983 1454983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(24-80)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9362.74 Da        Isoelectric Point: 9.8124

>T77504 WP_088198315.1 NZ_CP021813:1315743-1315997 [Sinorhizobium meliloti]
MNSKQRKTLAAVFKDPVSGTIEWAAIENLLVPAGADVIEGNGSRVKFEKDVIIASFHRPHPDKEAKRYQVRDAREFLMQI
GATP

Download         Length: 255 bp

>T77504 NZ_CP021813:1315743-1315997 [Sinorhizobium meliloti]
ATGAACAGCAAGCAGAGAAAGACCCTCGCGGCCGTATTCAAGGACCCGGTCTCGGGAACCATTGAATGGGCCGCTATAGA
GAACCTGCTTGTGCCTGCCGGAGCGGACGTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGTCATCATTG
CGAGCTTCCATCGACCTCATCCGGACAAGGAAGCAAAGCGTTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGCAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13234.88 Da        Isoelectric Point: 4.9920

>AT77504 WP_088198316.1 NZ_CP021813:1315994-1316350 [Sinorhizobium meliloti]
MNTMTYNGYHARIEFDAEDELFFGKIAGIADVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLSA

Download         Length: 357 bp

>AT77504 NZ_CP021813:1315994-1316350 [Sinorhizobium meliloti]
ATGAACACCATGACCTACAACGGGTATCACGCTCGCATCGAATTCGACGCTGAGGACGAACTGTTTTTCGGCAAGATTGC
AGGTATCGCCGATGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCAGTCGATGACT
ACCTCGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCTGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTCAACCAGTGGGCAGAAGAGGTGCTGGAAGAAGC
CGCCGACCATTTTGCCGAGGCGCGCCTGTCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References