Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 695603..696240 Replicon plasmid psymA
Accession NZ_CP021813
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO26_RS21745 Protein ID WP_088197975.1
Coordinates 695839..696240 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO26_RS21740 Protein ID WP_088197974.1
Coordinates 695603..695839 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS21710 (CDO26_21720) 691157..691540 + 384 WP_088197971.1 hypothetical protein -
CDO26_RS21715 (CDO26_21725) 691499..692701 - 1203 WP_088197972.1 IS256-like element ISRm3 family transposase -
CDO26_RS21725 (CDO26_21735) 692760..692994 + 235 Protein_715 DDE-type integrase/transposase/recombinase -
CDO26_RS21730 (CDO26_21740) 693161..694051 - 891 WP_234843387.1 effector protein NopP -
CDO26_RS21735 (CDO26_21745) 694302..695307 + 1006 Protein_717 IS5 family transposase -
CDO26_RS21740 (CDO26_21750) 695603..695839 + 237 WP_088197974.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CDO26_RS21745 (CDO26_21755) 695839..696240 + 402 WP_088197975.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO26_RS39995 697037..697384 - 348 WP_201271457.1 transposase -
CDO26_RS21755 (CDO26_21765) 698015..700989 - 2975 Protein_721 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1454983 1454983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14830.06 Da        Isoelectric Point: 5.1659

>T77502 WP_088197975.1 NZ_CP021813:695839-696240 [Sinorhizobium meliloti]
MARYMLDTNMCIYLMKNQPEQVARRFASCYVGDVVMSAITFAELEYGVSASDDPARELDNLAALAELITVEPFGITAARA
YGPVRMATRDRKKDHLDKLIASHAIALNTVLVTNNTRDFLAYPGLKLENWLDA

Download         Length: 402 bp

>T77502 NZ_CP021813:695839-696240 [Sinorhizobium meliloti]
ATGGCGCGCTACATGCTCGATACGAACATGTGTATCTACCTGATGAAAAACCAGCCGGAGCAGGTCGCCCGCCGCTTTGC
CAGTTGCTATGTGGGAGACGTGGTCATGTCCGCCATCACCTTCGCCGAACTCGAGTATGGTGTATCCGCATCCGATGATC
CCGCACGGGAACTTGATAATCTCGCAGCCCTGGCCGAACTGATCACCGTAGAGCCGTTTGGGATTACAGCAGCGCGTGCC
TATGGTCCGGTTCGAATGGCGACAAGAGACCGGAAGAAAGATCATCTCGATAAACTGATCGCGTCGCATGCAATCGCCCT
CAACACGGTGTTAGTGACCAACAACACGCGCGACTTCCTGGCGTATCCCGGACTGAAGCTCGAAAACTGGCTGGACGCGT
AA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9023.09 Da        Isoelectric Point: 5.6391

>AT77502 WP_088197974.1 NZ_CP021813:695603-695839 [Sinorhizobium meliloti]
MHTTKAFKNGNSQAVRIPAELAFDRTDVELEIERVGDELRIRPVHRSLAGVLDVFARFSPDFMRDGRESHEQDERDKI

Download         Length: 237 bp

>AT77502 NZ_CP021813:695603-695839 [Sinorhizobium meliloti]
ATGCATACCACCAAAGCTTTCAAGAATGGAAATTCGCAGGCCGTGCGTATCCCGGCCGAACTGGCGTTTGACCGAACCGA
TGTCGAGTTGGAAATCGAGCGCGTCGGCGACGAGCTTCGCATCCGTCCTGTGCATCGCTCCCTGGCCGGCGTTCTGGATG
TATTCGCCCGCTTCTCTCCGGATTTTATGCGTGACGGAAGAGAGTCCCATGAGCAAGACGAGCGGGATAAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References