Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 667489..668024 Replicon plasmid psymA
Accession NZ_CP021813
Organism Sinorhizobium meliloti strain M270

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CDO26_RS21565 Protein ID WP_088197957.1
Coordinates 667489..667764 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CDO26_RS21570 Protein ID WP_088197958.1
Coordinates 667764..668024 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO26_RS21535 (CDO26_21540) 662733..664145 + 1413 WP_164827361.1 FAD-binding oxidoreductase -
CDO26_RS21540 (CDO26_21545) 664142..665755 + 1614 WP_088197956.1 GMC family oxidoreductase N-terminal domain-containing protein -
CDO26_RS21545 (CDO26_21550) 665897..666103 - 207 Protein_680 FAD-dependent oxidoreductase -
CDO26_RS39060 666044..666343 + 300 WP_153416893.1 hypothetical protein -
CDO26_RS21550 (CDO26_21555) 666313..666567 + 255 Protein_682 integrase -
CDO26_RS39965 666804..667457 - 654 Protein_683 integrase -
CDO26_RS21565 (CDO26_21570) 667489..667764 - 276 WP_088197957.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO26_RS21570 (CDO26_21575) 667764..668024 - 261 WP_088197958.1 ribbon-helix-helix domain-containing protein Antitoxin
CDO26_RS38130 668225..668421 + 197 Protein_686 transposase -
CDO26_RS21585 (CDO26_21590) 669478..670506 - 1029 WP_088197960.1 LLM class flavin-dependent oxidoreductase -
CDO26_RS21590 (CDO26_21595) 670932..672047 - 1116 WP_088197961.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1454983 1454983


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10853.47 Da        Isoelectric Point: 10.8743

>T77501 WP_088197957.1 NZ_CP021813:c667764-667489 [Sinorhizobium meliloti]
MKLEWTRKAVSDLGRLHDFLAPVNRQAAARTVQSLTSAPARLLEQPRIGERLEEFDPREVRRILVGHYEIRYEIRQSTIY
VLRLWHTRESR

Download         Length: 276 bp

>T77501 NZ_CP021813:c667764-667489 [Sinorhizobium meliloti]
ATGAAGCTCGAGTGGACGCGTAAGGCAGTCTCCGATCTAGGGCGCCTGCATGATTTCCTGGCACCGGTAAATCGGCAAGC
TGCTGCTCGCACTGTGCAATCGTTGACAAGCGCTCCTGCGCGCCTGCTCGAACAACCGCGCATCGGCGAACGGCTGGAGG
AATTCGACCCACGAGAGGTGCGGCGAATTCTCGTTGGCCATTACGAAATACGGTATGAGATTCGGCAGTCGACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAATCACGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9685.09 Da        Isoelectric Point: 5.1200

>AT77501 WP_088197958.1 NZ_CP021813:c668024-667764 [Sinorhizobium meliloti]
METKVLTAHVPLPLAEKVDQIAARLERSRGWIVKQALTAWVDQEEERRRLTLEALADVDAGRVIEHHAVQAWADSLDSDK
PLPLPL

Download         Length: 261 bp

>AT77501 NZ_CP021813:c668024-667764 [Sinorhizobium meliloti]
ATGGAAACCAAGGTGCTGACCGCGCACGTGCCACTGCCACTCGCCGAGAAAGTCGATCAGATCGCCGCCCGCCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGCGTGATCGAGCACCATGCCGTTCAGGCCTGGGCCGACAGTCTTGACAGCGACAAG
CCGCTACCCTTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References