77487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 978060..978559 Replicon plasmid psymA
Accession NZ_CP021809
Organism Sinorhizobium meliloti strain Rm41

Toxin (Protein)


Gene name relE Uniprot ID Q92YA6
Locus tag CDO27_RS23540 Protein ID WP_010967939.1
Coordinates 978386..978559 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A843ZXX9
Locus tag CDO27_RS36335 Protein ID WP_014990215.1
Coordinates 978060..978389 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO27_RS23505 973737..974630 - 894 WP_010967943.1 LysR family transcriptional regulator -
CDO27_RS23510 974722..975165 + 444 WP_010967942.1 PACE efflux transporter -
CDO27_RS23515 975282..975620 + 339 WP_013845641.1 SDR family oxidoreductase -
CDO27_RS23520 975604..975945 - 342 Protein_947 hypothetical protein -
CDO27_RS23525 976329..977699 - 1371 WP_013845640.1 alpha/beta hydrolase -
CDO27_RS23530 977940..978125 - 186 WP_013845639.1 hypothetical protein -
CDO27_RS36335 978060..978389 + 330 WP_014990215.1 hypothetical protein Antitoxin
CDO27_RS23540 978386..978559 + 174 WP_010967939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDO27_RS23545 978657..978962 - 306 WP_013845638.1 hypothetical protein -
CDO27_RS23555 979282..979641 - 360 WP_013845635.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
CDO27_RS23560 980236..980487 + 252 WP_003534243.1 GlsB/YeaQ/YmgE family stress response membrane protein -
CDO27_RS23565 980515..981000 + 486 WP_010967936.1 YidB family protein -
CDO27_RS23570 981379..982695 - 1317 WP_013845634.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(3)-IIc htpB 1..1549593 1549593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-396)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6497.32 Da        Isoelectric Point: 5.7733

>T77487 WP_010967939.1 NZ_CP021809:978386-978559 [Sinorhizobium meliloti]
MKLVWARYALDDRDAIFSYIERENPRAAVHVDEEVVSAGRPLDFPESRRPGRIAGTP

Download         Length: 174 bp

>T77487 NZ_CP021809:978386-978559 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12067.72 Da        Isoelectric Point: 11.1401

>AT77487 WP_014990215.1 NZ_CP021809:978060-978389 [Sinorhizobium meliloti]
VSERLLLIALLALGPFRASQRHTGRPALLRRGPQTAAGAVEEHFIQLRAPLWLITLGGFSHREAHDAWFRAKVLRALEDT
RPDADDADADAHFQERRAAALRKAAAGDR

Download         Length: 330 bp

>AT77487 NZ_CP021809:978060-978389 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92YA6

Antitoxin

Source ID Structure
AlphaFold DB A0A843ZXX9

References