Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1019725..1020410 Replicon plasmid psymA
Accession NZ_CP021805
Organism Sinorhizobium meliloti strain T073

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDO28_RS23975 Protein ID WP_088196197.1
Coordinates 1019725..1020144 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CDO28_RS23980 Protein ID WP_088196198.1
Coordinates 1020141..1020410 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO28_RS23970 1019537..1019728 - 192 WP_088196196.1 hypothetical protein -
CDO28_RS23975 1019725..1020144 - 420 WP_088196197.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO28_RS23980 1020141..1020410 - 270 WP_088196198.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDO28_RS23985 1020548..1021014 + 467 Protein_937 LysR family transcriptional regulator -
CDO28_RS23990 1021104..1021979 - 876 WP_164831276.1 LysR family transcriptional regulator -
CDO28_RS24000 1022464..1022649 + 186 Protein_939 hypothetical protein -
CDO28_RS24005 1022706..1023086 - 381 WP_027992223.1 transcriptional regulator -
CDO28_RS24010 1023104..1023415 - 312 WP_003526630.1 type II toxin-antitoxin system HigB family toxin -
CDO28_RS24015 1023587..1024510 - 924 Protein_942 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB 1..1423499 1423499


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14703.93 Da        Isoelectric Point: 4.8722

>T77474 WP_088196197.1 NZ_CP021805:c1020144-1019725 [Sinorhizobium meliloti]
VSRLYMLDTNIVSELARNPQGAVTKRIAEVGPDAICVSIITAAELRYGCAKKGSSKLLAQIETILGSIQVLALDVPADAE
YGGIRAELEAAGKPIGPNDLFIAAHACMLGAVLVTANSSEFTRVRDLKVENWLDFTSSG

Download         Length: 420 bp

>T77474 NZ_CP021805:c1020144-1019725 [Sinorhizobium meliloti]
GTGAGCAGGCTCTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGATGCAATCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CATCGAAACTGCTGGCGCAGATCGAGACCATTCTTGGAAGTATACAAGTGCTTGCGCTCGATGTGCCAGCTGATGCCGAA
TACGGCGGCATCCGGGCTGAACTGGAGGCCGCTGGTAAGCCCATCGGCCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TATGCTTGGAGCGGTGCTGGTAACGGCCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10202.68 Da        Isoelectric Point: 4.5716

>AT77474 WP_088196198.1 NZ_CP021805:c1020410-1020141 [Sinorhizobium meliloti]
MPQLRHNEPTPPREAKLFRNNRSQAVRIPADFELPGDRVMIHRDGDRLIIEPVLRKNLLEVLAGLEPLGSEDEFPDVDET
LLPVKEIDL

Download         Length: 270 bp

>AT77474 NZ_CP021805:c1020410-1020141 [Sinorhizobium meliloti]
ATGCCCCAGCTCCGACACAACGAACCAACACCGCCAAGGGAAGCCAAGCTCTTCCGCAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCGGGCGATCGAGTGATGATCCATCGGGACGGAGATCGGCTGATAATAGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTGCTGGCTGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGACGAAACC
CTGCTGCCGGTGAAGGAAATCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References