Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 65053..65633 | Replicon | plasmid psymA |
Accession | NZ_CP021801 | ||
Organism | Sinorhizobium meliloti strain USDA1021 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q92XP1 |
Locus tag | CDO29_RS17450 | Protein ID | WP_010968151.1 |
Coordinates | 65053..65436 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | F7XCL0 |
Locus tag | CDO29_RS17455 | Protein ID | WP_013851145.1 |
Coordinates | 65433..65633 (-) | Length | 67 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDO29_RS17415 | 60120..60608 | + | 489 | WP_088203420.1 | hypothetical protein | - |
CDO29_RS36485 | 60621..61355 | + | 735 | WP_127570026.1 | acyltransferase | - |
CDO29_RS17430 | 61945..62933 | + | 989 | Protein_60 | IS21 family transposase | - |
CDO29_RS17435 | 62930..63811 | + | 882 | WP_088203423.1 | IS21-like element helper ATPase IstB | - |
CDO29_RS17445 | 64203..64577 | - | 375 | WP_088203424.1 | LysE family transporter | - |
CDO29_RS17450 | 65053..65436 | - | 384 | WP_010968151.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
CDO29_RS17455 | 65433..65633 | - | 201 | WP_013851145.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
CDO29_RS17460 | 65924..66325 | + | 402 | WP_014531161.1 | GFA family protein | - |
CDO29_RS17465 | 66402..67238 | - | 837 | WP_014531162.1 | helix-turn-helix transcriptional regulator | - |
CDO29_RS17470 | 67334..67657 | + | 324 | WP_017266777.1 | DUF1127 domain-containing protein | - |
CDO29_RS17475 | 67696..68424 | + | 729 | WP_014531163.1 | class I SAM-dependent methyltransferase | - |
CDO29_RS17480 | 68518..68664 | + | 147 | WP_017266778.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | htpB | 1..1412628 | 1412628 | |
- | flank | IS/Tn | - | - | 62930..63811 | 881 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14292.54 Da Isoelectric Point: 6.9172
>T77453 WP_010968151.1 NZ_CP021801:c65436-65053 [Sinorhizobium meliloti]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN
Download Length: 384 bp
>T77453 NZ_CP021801:c65436-65053 [Sinorhizobium meliloti]
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTATTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTTGGCAGCCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCAGGAGGTCATGATGATGATCGATCGCCACGCCATTTTTAGCATG
GGGATTGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTCCTCGATCAGCGAATGGCTTTGTGGACGAGAGACAAGCG
TTTGCAGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACGCGGAACTGA
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTATTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTTGGCAGCCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCAGGAGGTCATGATGATGATCGATCGCCACGCCATTTTTAGCATG
GGGATTGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTCCTCGATCAGCGAATGGCTTTGTGGACGAGAGACAAGCG
TTTGCAGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACGCGGAACTGA
Antitoxin
Download Length: 67 a.a. Molecular weight: 7096.22 Da Isoelectric Point: 11.1107
>AT77453 WP_013851145.1 NZ_CP021801:c65633-65433 [Sinorhizobium meliloti]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAK
Download Length: 201 bp
>AT77453 NZ_CP021801:c65633-65433 [Sinorhizobium meliloti]
ATGCGATCGACTATCAACCTCGACGACACTCTCATGGAAAGGGCTAAGTCCCTAACCGGCACAAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAAGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA
ATGCGATCGACTATCAACCTCGACGACACTCTCATGGAAAGGGCTAAGTCCCTAACCGGCACAAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAAGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q92XP1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7W6MID2 |