77449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2311964..2312625 Replicon chromosome
Accession NZ_CP021800
Organism Sinorhizobium meliloti strain USDA1021

Toxin (Protein)


Gene name vapC Uniprot ID Q92KY5
Locus tag CDO29_RS11680 Protein ID WP_010970565.1
Coordinates 2312221..2312625 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92KY4
Locus tag CDO29_RS11675 Protein ID WP_010970566.1
Coordinates 2311964..2312224 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDO29_RS11645 2307438..2308319 + 882 WP_010970570.1 pyridoxal kinase PdxY -
CDO29_RS11650 2308493..2309176 + 684 WP_010970569.1 carbonic anhydrase -
CDO29_RS11660 2309523..2310344 - 822 WP_013844939.1 lytic transglycosylase family protein -
CDO29_RS11665 2310517..2311551 - 1035 WP_088203296.1 aspartate-semialdehyde dehydrogenase -
CDO29_RS11670 2311665..2311835 - 171 WP_010970567.1 hypothetical protein -
CDO29_RS11675 2311964..2312224 + 261 WP_010970566.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDO29_RS11680 2312221..2312625 + 405 WP_010970565.1 type II toxin-antitoxin system VapC family toxin Toxin
CDO29_RS11685 2313144..2315033 + 1890 WP_014527006.1 MHS family MFS transporter -
CDO29_RS11690 2315134..2315841 - 708 WP_010970563.1 phosphatase PAP2 family protein -
CDO29_RS11695 2315970..2317082 - 1113 WP_003535893.1 3-isopropylmalate dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-124)

Antitoxin

(8-44)


Sequences


Toxin        


Download         Length: 135 a.a.        Molecular weight: 14507.71 Da        Isoelectric Point: 6.7257

>T77449 WP_010970565.1 NZ_CP021800:2312221-2312625 [Sinorhizobium meliloti]
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL

Download         Length: 405 bp

>T77449 NZ_CP021800:2312221-2312625 [Sinorhizobium meliloti]
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9903.16 Da        Isoelectric Point: 5.1253

>AT77449 WP_010970566.1 NZ_CP021800:2311964-2312224 [Sinorhizobium meliloti]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR

Download         Length: 261 bp

>AT77449 NZ_CP021800:2311964-2312224 [Sinorhizobium meliloti]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q92KY5


Antitoxin

Source ID Structure
AlphaFold DB Q92KY4

References