Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 2311964..2312625 | Replicon | chromosome |
Accession | NZ_CP021800 | ||
Organism | Sinorhizobium meliloti strain USDA1021 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q92KY5 |
Locus tag | CDO29_RS11680 | Protein ID | WP_010970565.1 |
Coordinates | 2312221..2312625 (+) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q92KY4 |
Locus tag | CDO29_RS11675 | Protein ID | WP_010970566.1 |
Coordinates | 2311964..2312224 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDO29_RS11645 | 2307438..2308319 | + | 882 | WP_010970570.1 | pyridoxal kinase PdxY | - |
CDO29_RS11650 | 2308493..2309176 | + | 684 | WP_010970569.1 | carbonic anhydrase | - |
CDO29_RS11660 | 2309523..2310344 | - | 822 | WP_013844939.1 | lytic transglycosylase family protein | - |
CDO29_RS11665 | 2310517..2311551 | - | 1035 | WP_088203296.1 | aspartate-semialdehyde dehydrogenase | - |
CDO29_RS11670 | 2311665..2311835 | - | 171 | WP_010970567.1 | hypothetical protein | - |
CDO29_RS11675 | 2311964..2312224 | + | 261 | WP_010970566.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
CDO29_RS11680 | 2312221..2312625 | + | 405 | WP_010970565.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
CDO29_RS11685 | 2313144..2315033 | + | 1890 | WP_014527006.1 | MHS family MFS transporter | - |
CDO29_RS11690 | 2315134..2315841 | - | 708 | WP_010970563.1 | phosphatase PAP2 family protein | - |
CDO29_RS11695 | 2315970..2317082 | - | 1113 | WP_003535893.1 | 3-isopropylmalate dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14507.71 Da Isoelectric Point: 6.7257
>T77449 WP_010970565.1 NZ_CP021800:2312221-2312625 [Sinorhizobium meliloti]
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL
VISHILDTNAVIALIGRKSDALVTRVLHSPQGIIGLPSVVAYELYFGAQKSAKAQHNLETLRLLMADFPILDFDRNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLRVEDWSL
Download Length: 405 bp
>T77449 NZ_CP021800:2312221-2312625 [Sinorhizobium meliloti]
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG
GTGATCTCCCATATTCTCGACACCAACGCCGTCATCGCTTTGATCGGGCGCAAATCGGATGCATTGGTCACCCGTGTACT
CCATAGCCCTCAGGGCATTATCGGGCTCCCGTCGGTCGTCGCGTATGAACTCTATTTTGGAGCGCAGAAAAGCGCGAAGG
CCCAACACAATCTCGAAACCCTGCGTTTGTTGATGGCGGATTTTCCGATCCTCGACTTCGACCGGAACGATGCCTTTGTC
GCAGGCGAGATCCGGGCCGCCCTTGCCGCGAAGGGTACGCCCATCGGACCTTATGACGTGCTGATTGCGGGACAGGCCAA
AGCCCGTGGATTGACGCTCGTCACCAACAATGTCGGCGAGTTCAATAGGGTTGAGAACCTGCGCGTGGAGGATTGGTCGC
TCTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9903.16 Da Isoelectric Point: 5.1253
>AT77449 WP_010970566.1 NZ_CP021800:2311964-2312224 [Sinorhizobium meliloti]
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR
MPHLARVFQSGNSQAVRLPKEFRFNVDRVEITQEGDALILRPHVEQGEQWSSLKAALARGMSEDFMMCGREQPEQQDRSE
LDAVFR
Download Length: 261 bp
>AT77449 NZ_CP021800:2311964-2312224 [Sinorhizobium meliloti]
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA
ATGCCCCATCTTGCACGGGTGTTCCAGTCCGGAAATTCGCAGGCCGTCCGCCTGCCTAAGGAATTCCGCTTCAACGTCGA
TCGCGTCGAAATCACGCAGGAAGGCGACGCGCTCATTCTCCGCCCGCACGTCGAGCAAGGCGAGCAGTGGTCATCGCTGA
AGGCGGCACTTGCCCGTGGCATGAGTGAAGACTTCATGATGTGCGGGCGCGAGCAGCCGGAACAGCAGGATCGGTCGGAA
CTCGACGCGGTATTTCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|