Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-VagC |
Location | 2406750..2407423 | Replicon | chromosome |
Accession | NZ_CP021793 | ||
Organism | Sinorhizobium meliloti strain USDA1157 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | CDO31_RS12495 | Protein ID | WP_010969926.1 |
Coordinates | 2407019..2407423 (+) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | H0GA10 |
Locus tag | CDO31_RS12490 | Protein ID | WP_003536345.1 |
Coordinates | 2406750..2407022 (+) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CDO31_RS12470 | 2402741..2404381 | - | 1641 | WP_003536336.1 | ABC transporter substrate-binding protein | - |
CDO31_RS12475 | 2404429..2405484 | - | 1056 | WP_088194531.1 | dipeptidase | - |
CDO31_RS12480 | 2405664..2406005 | - | 342 | WP_003536339.1 | EamA family transporter | - |
CDO31_RS12485 | 2406053..2406613 | - | 561 | WP_010969925.1 | TetR/AcrR family transcriptional regulator | - |
CDO31_RS12490 | 2406750..2407022 | + | 273 | WP_003536345.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
CDO31_RS12495 | 2407019..2407423 | + | 405 | WP_010969926.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
CDO31_RS12500 | 2407551..2407943 | + | 393 | WP_003536349.1 | globin | - |
CDO31_RS12505 | 2407949..2408323 | + | 375 | WP_010969927.1 | DUF423 domain-containing protein | - |
CDO31_RS12510 | 2408446..2408706 | + | 261 | WP_010969928.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
CDO31_RS12515 | 2408821..2409135 | - | 315 | WP_003536354.1 | antibiotic biosynthesis monooxygenase | - |
CDO31_RS12520 | 2409148..2409414 | - | 267 | WP_010969929.1 | hypothetical protein | - |
CDO31_RS12525 | 2409467..2409880 | - | 414 | WP_003536357.1 | DUF2325 domain-containing protein | - |
CDO31_RS12530 | 2410088..2411014 | - | 927 | WP_010969930.1 | energy transducer TonB | - |
CDO31_RS12535 | 2411055..2411489 | - | 435 | WP_010969931.1 | hypothetical protein | - |
CDO31_RS12540 | 2411719..2411859 | + | 141 | WP_010969932.1 | hemin uptake protein HemP | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14747.98 Da Isoelectric Point: 5.1974
>T77420 WP_010969926.1 NZ_CP021793:2407019-2407423 [Sinorhizobium meliloti]
MNGYLLDTNIISDVIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYALDLTLVTDNIREFSRVRGLSLENWLER
MNGYLLDTNIISDVIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYALDLTLVTDNIREFSRVRGLSLENWLER
Download Length: 405 bp
>T77420 NZ_CP021793:2407019-2407423 [Sinorhizobium meliloti]
TTGAACGGCTATCTTCTCGATACGAACATCATCAGCGACGTCATTCACAATCCGTTCGGACCGGCTGCGCAACGCATCGA
ACGGATCGGCCCGAAGGAGATTTACACCAGCATCGTCGTCGCGTCCGAGTTGCGGTATGGTTGCGCAAAAAAGGGATCGG
CGAAGTTGCTCGCCAAGGTCGAAAGCTTGCTGGAAATCGTCCCGGTGCTGCCATTGGATATTCCGGCCGACACCCGATAT
GGCAGCATTCGTGCGGAATTGGAGTCTCTGGGGCAGACCATCGGCTCCAACGATCTGTTGATTGCCGCGCATGCATATGC
GCTGGACCTGACGCTGGTGACGGACAATATCCGTGAGTTCAGCCGCGTTCGTGGCCTTAGTCTGGAAAACTGGCTTGAGC
GATAG
TTGAACGGCTATCTTCTCGATACGAACATCATCAGCGACGTCATTCACAATCCGTTCGGACCGGCTGCGCAACGCATCGA
ACGGATCGGCCCGAAGGAGATTTACACCAGCATCGTCGTCGCGTCCGAGTTGCGGTATGGTTGCGCAAAAAAGGGATCGG
CGAAGTTGCTCGCCAAGGTCGAAAGCTTGCTGGAAATCGTCCCGGTGCTGCCATTGGATATTCCGGCCGACACCCGATAT
GGCAGCATTCGTGCGGAATTGGAGTCTCTGGGGCAGACCATCGGCTCCAACGATCTGTTGATTGCCGCGCATGCATATGC
GCTGGACCTGACGCTGGTGACGGACAATATCCGTGAGTTCAGCCGCGTTCGTGGCCTTAGTCTGGAAAACTGGCTTGAGC
GATAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 10334.02 Da Isoelectric Point: 6.3950
>AT77420 WP_003536345.1 NZ_CP021793:2406750-2407022 [Sinorhizobium meliloti]
MPVPLPSSRPKEVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPIARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF
MPVPLPSSRPKEVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPIARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF
Download Length: 273 bp
>AT77420 NZ_CP021793:2406750-2407022 [Sinorhizobium meliloti]
ATGCCCGTCCCGTTGCCGTCATCGCGACCTAAAGAAGTAAAGCTGTTCCGCAATAACCGCAGCCAGGCAGTCCGTATTCC
TGCGGAGTTCGAGTTGCCTGGAGACCGTGTGTTGATCCGTCGCGAAGGAACGAGACTCATTATCGAACCGATAGCCAGGC
CAGCCGATATCGTGGAGCTTCTCGCGGAGTGGAAGAAGGAAGCTCCCCTCGGACCTGAAGACCGGTTCCCGGATGTTGAG
GATATACCCGCCCGGCCGGAGAAAATCTTTTGA
ATGCCCGTCCCGTTGCCGTCATCGCGACCTAAAGAAGTAAAGCTGTTCCGCAATAACCGCAGCCAGGCAGTCCGTATTCC
TGCGGAGTTCGAGTTGCCTGGAGACCGTGTGTTGATCCGTCGCGAAGGAACGAGACTCATTATCGAACCGATAGCCAGGC
CAGCCGATATCGTGGAGCTTCTCGCGGAGTGGAAGAAGGAAGCTCCCCTCGGACCTGAAGACCGGTTCCCGGATGTTGAG
GATATACCCGCCCGGCCGGAGAAAATCTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|