Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4086862..4087541 | Replicon | chromosome |
| Accession | NZ_CP021776 | ||
| Organism | Enterobacter cloacae complex sp. strain AR_0053 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | AM432_RS20320 | Protein ID | WP_032608412.1 |
| Coordinates | 4087200..4087541 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | AM432_RS20315 | Protein ID | WP_020456353.1 |
| Coordinates | 4086862..4087179 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM432_RS20275 | 4082151..4082975 | + | 825 | Protein_3878 | DUF945 domain-containing protein | - |
| AM432_RS20280 (AM432_20420) | 4083184..4083867 | + | 684 | WP_020456346.1 | DeoR family transcriptional regulator | - |
| AM432_RS26305 | 4083920..4084042 | + | 123 | WP_020456347.1 | hypothetical protein | - |
| AM432_RS20285 (AM432_20425) | 4084106..4084972 | + | 867 | WP_032608409.1 | hypothetical protein | - |
| AM432_RS20290 (AM432_20430) | 4085100..4085300 | + | 201 | WP_050596949.1 | DUF905 family protein | - |
| AM432_RS20295 (AM432_20435) | 4085406..4085864 | + | 459 | WP_032608410.1 | antirestriction protein | - |
| AM432_RS20300 (AM432_20440) | 4085874..4086092 | + | 219 | WP_020456350.1 | hypothetical protein | - |
| AM432_RS20305 (AM432_20445) | 4086135..4086614 | + | 480 | WP_020456351.1 | DNA repair protein RadC | - |
| AM432_RS20310 (AM432_20450) | 4086623..4086844 | + | 222 | WP_032608411.1 | DUF987 domain-containing protein | - |
| AM432_RS20315 (AM432_20455) | 4086862..4087179 | + | 318 | WP_020456353.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AM432_RS20320 (AM432_20460) | 4087200..4087541 | + | 342 | WP_032608412.1 | TA system toxin CbtA family protein | Toxin |
| AM432_RS20325 (AM432_20465) | 4087796..4088803 | + | 1008 | WP_020456355.1 | restriction endonuclease | - |
| AM432_RS20330 (AM432_20470) | 4088984..4089853 | - | 870 | WP_032608413.1 | HNH endonuclease | - |
| AM432_RS20335 (AM432_20480) | 4090154..4090627 | + | 474 | WP_072163380.1 | SymE family type I addiction module toxin | - |
| AM432_RS20340 (AM432_20485) | 4090707..4091078 | - | 372 | WP_032608414.1 | hypothetical protein | - |
| AM432_RS20345 (AM432_20490) | 4091193..4091441 | - | 249 | WP_032608415.1 | bacteriocin immunity protein | - |
| AM432_RS20350 (AM432_20495) | 4091500..4091724 | - | 225 | WP_032608417.1 | colicin E3-like toxin immunity protein | - |
| AM432_RS20355 (AM432_20500) | 4091797..4092048 | - | 252 | WP_032608418.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA | - | 4056482..4107938 | 51456 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12747.73 Da Isoelectric Point: 9.0060
>T77398 WP_032608412.1 NZ_CP021776:4087200-4087541 [Enterobacter cloacae complex sp.]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T77398 NZ_CP021776:4087200-4087541 [Enterobacter cloacae complex sp.]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11846.39 Da Isoelectric Point: 5.5403
>AT77398 WP_020456353.1 NZ_CP021776:4086862-4087179 [Enterobacter cloacae complex sp.]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 318 bp
>AT77398 NZ_CP021776:4086862-4087179 [Enterobacter cloacae complex sp.]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|