Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2420776..2421433 Replicon chromosome
Accession NZ_CP021776
Organism Enterobacter cloacae complex sp. strain AR_0053

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag AM432_RS12015 Protein ID WP_022649305.1
Coordinates 2420776..2421186 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM432_RS12020 Protein ID WP_003863437.1
Coordinates 2421167..2421433 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM432_RS11995 (AM432_11985) 2416774..2418507 - 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -
AM432_RS12000 (AM432_11990) 2418513..2419226 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM432_RS12005 (AM432_11995) 2419255..2420151 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM432_RS12010 (AM432_12000) 2420253..2420774 + 522 WP_003863440.1 flavodoxin FldB -
AM432_RS12015 (AM432_12005) 2420776..2421186 - 411 WP_022649305.1 protein YgfX Toxin
AM432_RS12020 (AM432_12010) 2421167..2421433 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM432_RS12025 (AM432_12015) 2421728..2422708 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM432_RS12030 (AM432_12020) 2422794..2423453 - 660 WP_003863433.1 hemolysin III family protein -
AM432_RS12035 (AM432_12030) 2423720..2424451 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
AM432_RS12040 (AM432_12035) 2424568..2426001 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T77395 WP_022649305.1 NZ_CP021776:c2421186-2420776 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T77395 NZ_CP021776:c2421186-2420776 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT77395 WP_003863437.1 NZ_CP021776:c2421433-2421167 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT77395 NZ_CP021776:c2421433-2421167 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References