77381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5532947..5533555 Replicon chromosome
Accession NZ_CP021775
Organism Pseudomonas aeruginosa strain Pa58

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag CDL16_RS26915 Protein ID WP_003114156.1
Coordinates 5532947..5533294 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag CDL16_RS26920 Protein ID WP_003114155.1
Coordinates 5533304..5533555 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDL16_RS26885 5528306..5528578 + 273 WP_003134390.1 cysteine-rich CWC family protein -
CDL16_RS26890 5528578..5529270 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
CDL16_RS26895 5529406..5530449 + 1044 WP_003134392.1 L,D-transpeptidase -
CDL16_RS26900 5530529..5531266 + 738 WP_003124252.1 murein L,D-transpeptidase catalytic domain family protein -
CDL16_RS26905 5531718..5532620 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
CDL16_RS26915 5532947..5533294 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDL16_RS26920 5533304..5533555 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CDL16_RS26925 5533769..5534751 - 983 Protein_5208 tyrosine-type recombinase/integrase -
CDL16_RS26930 5534751..5536043 - 1293 WP_003134394.1 hypothetical protein -
CDL16_RS26935 5536273..5537556 - 1284 WP_023127773.1 hypothetical protein -
CDL16_RS26940 5537560..5537916 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5532947..5560561 27614


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T77381 WP_003114156.1 NZ_CP021775:c5533294-5532947 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T77381 NZ_CP021775:c5533294-5532947 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT77381 WP_003114155.1 NZ_CP021775:c5533555-5533304 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT77381 NZ_CP021775:c5533555-5533304 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References