77374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 157620..158125 Replicon chromosome
Accession NZ_CP021775
Organism Pseudomonas aeruginosa strain Pa58

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CDL16_RS00730 Protein ID WP_003083773.1
Coordinates 157620..157901 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CDL16_RS00735 Protein ID WP_003083775.1
Coordinates 157898..158125 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDL16_RS00705 152871..154220 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
CDL16_RS00710 154269..154955 + 687 WP_003083762.1 FadR family transcriptional regulator -
CDL16_RS00715 155056..155790 + 735 WP_003128333.1 GntR family transcriptional regulator -
CDL16_RS00720 155994..156380 + 387 WP_003083767.1 aegerolysin family protein -
CDL16_RS00725 156412..157320 - 909 WP_003083769.1 LysR family transcriptional regulator -
CDL16_RS00730 157620..157901 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CDL16_RS00735 157898..158125 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CDL16_RS00740 158301..158921 - 621 WP_003101226.1 hypothetical protein -
CDL16_RS00745 159022..159522 + 501 WP_003128336.1 LEA type 2 family protein -
CDL16_RS00750 159595..159936 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CDL16_RS00755 160018..161445 - 1428 WP_003083784.1 GABA permease -
CDL16_RS00760 161614..163107 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T77374 WP_003083773.1 NZ_CP021775:c157901-157620 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T77374 NZ_CP021775:c157901-157620 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT77374 WP_003083775.1 NZ_CP021775:c158125-157898 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT77374 NZ_CP021775:c158125-157898 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References