77370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2631437..2631990 Replicon chromosome
Accession NZ_CP021774
Organism Pseudomonas aeruginosa strain Pa124

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag CDG41_RS12680 Protein ID WP_010953434.1
Coordinates 2631697..2631990 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A431XAN4
Locus tag CDG41_RS12675 Protein ID WP_003155922.1
Coordinates 2631437..2631709 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDG41_RS12670 2631068..2631313 + 246 WP_034065762.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CDG41_RS12675 2631437..2631709 + 273 WP_003155922.1 CopG family ribbon-helix-helix protein Antitoxin
CDG41_RS12680 2631697..2631990 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDG41_RS12685 2631984..2633393 - 1410 WP_034065764.1 site-specific integrase -
CDG41_RS12690 2633810..2634511 - 702 WP_031640384.1 hypothetical protein -
CDG41_RS12695 2634627..2634773 + 147 Protein_2452 DNA binding protein -
CDG41_RS33955 2634901..2635977 - 1077 WP_049875006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2597111..2640816 43705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T77370 WP_010953434.1 NZ_CP021774:2631697-2631990 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T77370 NZ_CP021774:2631697-2631990 [Pseudomonas aeruginosa]
GTGCCACGACTGATTGTCACTGAAGGCGCGGCGAAGGGCTTGGAGCGTTGCCGGCGATTCCTCTCCGATAAAGATCCGCA
AGTCGCGCGCCGCGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGCCCATTTC
CAGATCTGCCTGAGCTGCGTGAGCTCATCATCGAGTTTGGGGACTCAGGTTACGTCGCGCTGTATCGCTATGAGCGCGCA
GATGACACAGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10369.53 Da        Isoelectric Point: 6.0804

>AT77370 WP_003155922.1 NZ_CP021774:2631437-2631709 [Pseudomonas aeruginosa]
MATSIKIDDELKGRIQHLAGLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGRHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT77370 NZ_CP021774:2631437-2631709 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGAGCTGAAAGGTCGCATTCAGCATTTGGCTGGTTTGCGGCAGCGTTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGCGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCGTATCAGGAAACCGGCAGGCATTTGACCGGCCAAGAGGCTCGCACCTGGCTTGGTAGCTGGGGTACAGAT
GCTGAGGCAGAGCTTCCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB A0A431XAN4

References