Detailed information of TA system TA077365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 1454529..1455637
• Replicon: chromosome
• Accession: NZ_CP021773
• Organism: Streptococcus agalactiae strain B105

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: A0A3S8RBH6
• Locus tag: CCZ24_RS07300
• Protein ID: WP_071661597.1
• Coordinates: 1454529..1455398 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: CCZ24_RS07305
• Protein ID: WP_000205227.1
• Coordinates: 1455413..1455637 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCZ24_RS07265	1449783..1450343	-	561	Protein_1386	zinc ribbon domain-containing protein	-
CCZ24_RS07270	1450429..1450887	+	459	WP_002325145.1	hypothetical protein	-
CCZ24_RS07275	1450938..1451189	-	252	WP_002294510.1	hypothetical protein	-
CCZ24_RS07280	1451407..1452215	-	809	Protein_1389	aminoglycoside nucleotidyltransferase ANT(9)	-
CCZ24_RS07285	1452347..1452874	-	528	WP_002294507.1	adenine phosphoribosyltransferase	-
CCZ24_RS07290	1452918..1453781	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
CCZ24_RS07295	1453814..1454548	-	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
CCZ24_RS07300	1454529..1455398	-	870	WP_071661597.1	nucleotidyltransferase domain-containing protein	Toxin
CCZ24_RS07305	1455413..1455637	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
CCZ24_RS07310	1455780..1457324	-	1545	WP_071659949.1	recombinase family protein	-
CCZ24_RS07315	1457344..1457760	-	417	WP_000323438.1	recombinase	-
CCZ24_RS07320	1457761..1458057	-	297	WP_002360685.1	hypothetical protein	-
CCZ24_RS11985	1458094..1458258	-	165	Protein_1398	DNA recombinase	-
CCZ24_RS07325	1458569..1459246	-	678	Protein_1399	DNA topoisomerase	-
CCZ24_RS07330	1459262..1459864	-	603	WP_001062586.1	recombinase family protein	-
CCZ24_RS11990	1459878..1460048	-	171	WP_000713595.1	hypothetical protein	-
CCZ24_RS07335	1460251..1460424	-	174	WP_002779755.1	cysteine-rich KTR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32902.55 Da
• Isoelectric Point: 4.9770

>T77365 WP_071661597.1 NZ_CP021773:c1455398-1454529 [Streptococcus agalactiae]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T77365 NZ_CP021773:c1455398-1454529 [Streptococcus agalactiae]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGTATCAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAACATAAACCTGAAAAATATACCGAG
AAGGTAAATCATATTTTTGAAGTACTCGGTATCTCACTTTTTGAATGCTACGATATGACCGAGAAACTTTATAAAGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT77365 WP_000205227.1 NZ_CP021773:c1455637-1455413 [Streptococcus agalactiae]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT77365 NZ_CP021773:c1455637-1455413 [Streptococcus agalactiae]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Structures

Toxin

• AlphaFold DB: A0A3S8RBH6