Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1435812..1436244 Replicon chromosome
Accession NZ_CP021773
Organism Streptococcus agalactiae strain B105

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag CCZ24_RS07155 Protein ID WP_001284310.1
Coordinates 1435812..1435970 (-) Length 53 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag CCZ24_RS07160 Protein ID WP_000301765.1
Coordinates 1435972..1436244 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCZ24_RS07120 1431134..1432299 - 1166 Protein_1361 type IV secretory system conjugative DNA transfer family protein -
CCZ24_RS07125 1432292..1432783 - 492 WP_000011313.1 hypothetical protein -
CCZ24_RS07130 1432934..1433602 - 669 Protein_1363 zeta toxin family protein -
CCZ24_RS07145 1434173..1435039 - 867 WP_001255868.1 aminoglycoside 6-adenylyltransferase AadE -
CCZ24_RS07150 1435215..1435760 - 546 WP_001071501.1 AAA family ATPase -
CCZ24_RS07155 1435812..1435970 - 159 WP_001284310.1 zeta toxin family protein Toxin
CCZ24_RS07160 1435972..1436244 - 273 WP_000301765.1 antitoxin Antitoxin
CCZ24_RS07165 1436262..1436471 - 210 WP_000527318.1 peptide-binding protein -
CCZ24_RS07170 1436569..1437465 - 897 WP_001809760.1 ParA family protein -
CCZ24_RS07175 1437554..1437838 - 285 WP_073459356.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
CCZ24_RS07185 1437984..1438721 - 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
CCZ24_RS07190 1438846..1438929 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
CCZ24_RS07195 1438978..1439061 - 84 Protein_1373 peptide-binding protein -
CCZ24_RS07200 1439471..1440265 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
CCZ24_RS07205 1440358..1440609 - 252 Protein_1375 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / erm(B) / aph(3')-III / lnu(B) / lsa(E) cylK / cylJ / cylI / cylF / cylE / cylB / cylA / cylZ / acpC / cylG / cylD / cylX 1369674..1453748 84074
- inside IScluster/Tn ant(6)-Ia / erm(B) / aph(3')-III / lnu(B) / lsa(E) - 1434173..1453781 19608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-50)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5790.55 Da        Isoelectric Point: 10.3088

>T77363 WP_001284310.1 NZ_CP021773:c1435970-1435812 [Streptococcus agalactiae]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRRR

Download         Length: 159 bp

>T77363 NZ_CP021773:c1435970-1435812 [Streptococcus agalactiae]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGAAGAAGATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT77363 WP_000301765.1 NZ_CP021773:c1436244-1435972 [Streptococcus agalactiae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT77363 NZ_CP021773:c1436244-1435972 [Streptococcus agalactiae]
ATGGCAGTTACGTATGAAAAAACTTTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References