Detailed information of TA system TA077360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1342926..1343550
• Replicon: chromosome
• Accession: NZ_CP021772
• Organism: Streptococcus agalactiae strain B111

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: CDH81_RS06770
• Protein ID: WP_000253103.1
• Coordinates: 1342926..1343273 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: CDH81_RS06775
• Protein ID: WP_000543070.1
• Coordinates: 1343263..1343550 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDH81_RS06750	1338641..1338997	-	357	WP_000105935.1	DUF1304 domain-containing protein	-
CDH81_RS06755	1339064..1341382	-	2319	WP_000883417.1	YhgE/Pip domain-containing protein	-
CDH81_RS06760	1341521..1342060	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
CDH81_RS06765	1342146..1342442	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
CDH81_RS06770	1342926..1343273	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDH81_RS06775	1343263..1343550	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CDH81_RS06780	1343619..1343996	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
CDH81_RS06785	1343971..1344123	-	153	Protein_1304	DUF1492 domain-containing protein	-
CDH81_RS06790	1344130..1344618	-	489	WP_000891152.1	hypothetical protein	-
CDH81_RS06795	1344691..1345248	-	558	WP_001258764.1	hypothetical protein	-
CDH81_RS06800	1345406..1345579	-	174	WP_000694573.1	hypothetical protein	-
CDH81_RS06805	1345576..1345833	-	258	WP_001069293.1	hypothetical protein	-
CDH81_RS06810	1346126..1347520	-	1395	WP_000656430.1	hypothetical protein	-
CDH81_RS06815	1347532..1348389	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1342146..1359425	17279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T77360 WP_000253103.1 NZ_CP021772:c1343273-1342926 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T77360 NZ_CP021772:c1343273-1342926 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT77360 WP_000543070.1 NZ_CP021772:c1343550-1343263 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT77360 NZ_CP021772:c1343550-1343263 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5