Detailed information of TA system TA077358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 69020..69632
• Replicon: chromosome
• Accession: NZ_CP021771
• Organism: Streptococcus agalactiae strain B507

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: CDH84_RS00400
• Protein ID: WP_000384860.1
• Coordinates: 69020..69355 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: CDH84_RS00405
• Protein ID: WP_000259017.1
• Coordinates: 69345..69632 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDH84_RS00370	64218..64859	+	642	WP_000591144.1	hypothetical protein	-
CDH84_RS00380	65159..66034	+	876	WP_000421240.1	hypothetical protein	-
CDH84_RS00385	66070..66504	+	435	WP_001220479.1	hypothetical protein	-
CDH84_RS00390	66821..68077	+	1257	WP_000122836.1	plasmid recombination protein	-
CDH84_RS00395	68245..68715	+	471	WP_000130119.1	hypothetical protein	-
CDH84_RS00400	69020..69355	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDH84_RS00405	69345..69632	-	288	WP_000259017.1	hypothetical protein	Antitoxin
CDH84_RS00410	70139..70429	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
CDH84_RS00415	70531..70938	+	408	WP_000749954.1	hypothetical protein	-
CDH84_RS00420	70938..71498	+	561	WP_001865562.1	hypothetical protein	-
CDH84_RS00425	71471..72151	+	681	WP_001865565.1	hypothetical protein	-
CDH84_RS00430	72136..72522	+	387	WP_000259069.1	hypothetical protein	-
CDH84_RS00435	72556..72837	+	282	WP_000052406.1	hypothetical protein	-
CDH84_RS00455	73680..74540	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T77358 WP_000384860.1 NZ_CP021771:c69355-69020 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77358 NZ_CP021771:c69355-69020 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77358 WP_000259017.1 NZ_CP021771:c69632-69345 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77358 NZ_CP021771:c69632-69345 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6