Detailed information of TA system TA077355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 6297..6909
• Replicon: chromosome
• Accession: NZ_CP021770
• Organism: Streptococcus agalactiae strain B508

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: CDH83_RS00055
• Protein ID: WP_000384859.1
• Coordinates: 6297..6632 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: CDH83_RS00060
• Protein ID: WP_000259017.1
• Coordinates: 6622..6909 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDH83_RS00025	1495..2136	+	642	WP_000591145.1	hypothetical protein	-
CDH83_RS00035	2436..3311	+	876	WP_000421240.1	hypothetical protein	-
CDH83_RS00040	3347..3781	+	435	WP_001220479.1	hypothetical protein	-
CDH83_RS00045	4098..5354	+	1257	WP_000122836.1	plasmid recombination protein	-
CDH83_RS00050	5522..5992	+	471	WP_000130119.1	hypothetical protein	-
CDH83_RS00055	6297..6632	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDH83_RS00060	6622..6909	-	288	WP_000259017.1	hypothetical protein	Antitoxin
CDH83_RS00065	7416..7706	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
CDH83_RS00070	7808..8215	+	408	WP_000749954.1	hypothetical protein	-
CDH83_RS00075	8215..8775	+	561	WP_001865562.1	hypothetical protein	-
CDH83_RS00080	8748..9428	+	681	WP_001865565.1	hypothetical protein	-
CDH83_RS00085	9413..9799	+	387	WP_000259069.1	hypothetical protein	-
CDH83_RS00090	9833..10114	+	282	WP_000052406.1	hypothetical protein	-
CDH83_RS00110	10957..11817	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T77355 WP_000384859.1 NZ_CP021770:c6632-6297 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77355 NZ_CP021770:c6632-6297 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77355 WP_000259017.1 NZ_CP021770:c6909-6622 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77355 NZ_CP021770:c6909-6622 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6