Detailed information of TA system TA077354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 233557..234169
• Replicon: chromosome
• Accession: NZ_CP021769
• Organism: Streptococcus agalactiae strain B509

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: CDH85_RS01315
• Protein ID: WP_000384860.1
• Coordinates: 233834..234169 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: CDH85_RS01310
• Protein ID: WP_000259017.1
• Coordinates: 233557..233844 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDH85_RS01260	228648..229508	-	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-
CDH85_RS01280	230351..230632	-	282	WP_000052406.1	hypothetical protein	-
CDH85_RS01285	230666..231052	-	387	WP_112435740.1	hypothetical protein	-
CDH85_RS01290	231037..231717	-	681	WP_001865565.1	hypothetical protein	-
CDH85_RS01295	231690..232250	-	561	WP_001865562.1	hypothetical protein	-
CDH85_RS01300	232250..232658	-	409	Protein_217	hypothetical protein	-
CDH85_RS01305	232760..233050	-	291	WP_000078283.1	WXG100 family type VII secretion target	-
CDH85_RS01310	233557..233844	+	288	WP_000259017.1	hypothetical protein	Antitoxin
CDH85_RS01315	233834..234169	+	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDH85_RS01320	234474..234944	-	471	WP_000130119.1	hypothetical protein	-
CDH85_RS01325	235112..236368	-	1257	WP_000122836.1	plasmid recombination protein	-
CDH85_RS01330	236685..237119	-	435	WP_001220479.1	hypothetical protein	-
CDH85_RS01335	237155..238030	-	876	WP_000421240.1	hypothetical protein	-
CDH85_RS01345	238330..238971	-	642	WP_000591144.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T77354 WP_000384860.1 NZ_CP021769:233834-234169 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T77354 NZ_CP021769:233834-234169 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT77354 WP_000259017.1 NZ_CP021769:233557-233844 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT77354 NZ_CP021769:233557-233844 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6