Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1683247..1684864 Replicon plasmid unnamed
Accession NZ_CP021767
Organism Ralstonia solanacearum strain RS 489

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CDC59_RS22555 Protein ID WP_064046648.1
Coordinates 1683518..1684864 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CDC59_RS22550 Protein ID WP_064046647.1
Coordinates 1683247..1683513 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC59_RS22520 1678471..1678947 + 477 WP_064046643.1 RidA family protein -
CDC59_RS22525 1679048..1679884 + 837 WP_097909638.1 AraC family transcriptional regulator -
CDC59_RS22530 1679887..1681005 + 1119 WP_064046645.1 peptidase -
CDC59_RS22535 1681044..1681427 - 384 WP_013208661.1 VOC family protein -
CDC59_RS22540 1681680..1682114 + 435 WP_043945889.1 PGDYG domain-containing protein -
CDC59_RS22545 1682130..1682981 - 852 WP_097909761.1 hypothetical protein -
CDC59_RS22550 1683247..1683513 + 267 WP_064046647.1 helix-turn-helix domain-containing protein Antitoxin
CDC59_RS22555 1683518..1684864 + 1347 WP_064046648.1 type II toxin-antitoxin system HipA family toxin Toxin
CDC59_RS22560 1684952..1685848 + 897 WP_003265840.1 DUF2236 domain-containing protein -
CDC59_RS22565 1685857..1687428 - 1572 WP_064046651.1 MFS transporter -
CDC59_RS22570 1687527..1688474 - 948 WP_097909639.1 LysR family transcriptional regulator -
CDC59_RS22575 1688613..1689239 + 627 WP_013208668.1 FMN-dependent NADH-azoreductase -
CDC59_RS24590 1689386..1689532 - 147 WP_042590539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1999547 1999547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-409)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49583.80 Da        Isoelectric Point: 7.4099

>T77350 WP_064046648.1 NZ_CP021767:1683518-1684864 [Ralstonia solanacearum]
MGRRSHTRALGLWMNGTHVGRWELHPHQGDVLKYAASWVAAPEGRPLSLSLPFTPDNAPHKGPAVRAYFENLLPDSRDIR
ERIARRFQAGTTEAFDLLEQIGRDCIGALQVLPADMAPPATGDLDAEPLTEAQIAQTLRETVAPPPLGGMPEDDGHFRIS
IAGAQEKTALLQIDGRWYRPRGATPTSHIFKLPMGLVGNMQLDLSESVENEWLCALVLRAYGLPVAHCQPQVFEDQKVLA
VERFDRMWWDHGGKRLIRLPQEDMCQATATPPHLKYEADGGPGIDRIMGLLDGSAHREADRLTLFRSQVLFWMLRAPDGH
AKNFSLALRPGGAYALTPLYDVMSAYPLLGEGPGKLSAHRIRLAMAVRAKNAHWKMQDIQRRHWLGLGQRYGLVTSDGAD
TASIVDNLVTRTPEVIRTVRAMLPEGFPQPLADRILQGLQHAADKLAG

Download         Length: 1347 bp

>T77350 NZ_CP021767:1683518-1684864 [Ralstonia solanacearum]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCGCTGGGAGCTGCACCCGCA
CCAGGGCGACGTGCTGAAGTACGCGGCATCCTGGGTGGCCGCGCCCGAGGGGCGGCCCCTGTCGCTGTCCCTGCCCTTCA
CGCCGGACAACGCGCCCCACAAAGGCCCGGCGGTCCGGGCGTATTTCGAAAACCTCCTGCCCGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGCTTCCAGGCCGGTACGACCGAGGCGTTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAAGTGCTGCCGGCCGACATGGCCCCACCGGCCACGGGCGACCTCGACGCGGAACCGCTGACCGAGGCGCAGA
TCGCACAGACGCTGCGGGAGACCGTCGCCCCGCCGCCCCTGGGCGGCATGCCGGAAGACGACGGCCATTTCCGCATCTCG
ATCGCCGGCGCGCAGGAAAAGACGGCCCTCCTCCAGATCGACGGACGCTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCTGGTCGGCAACATGCAACTGGACCTCAGCGAGTCGGTGGAAAACGAATGGCTGT
GCGCCCTGGTGCTGCGGGCGTATGGCCTGCCCGTCGCGCACTGCCAGCCGCAGGTGTTCGAAGACCAGAAGGTGCTCGCC
GTGGAGCGGTTCGACCGCATGTGGTGGGACCACGGCGGCAAACGGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
CACAGCGACGCCCCCGCACCTGAAGTACGAAGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCACCGGGAAGCCGACCGCCTGACGCTGTTCCGCAGCCAAGTGCTGTTCTGGATGCTGCGCGCGCCCGATGGCCAT
GCGAAGAACTTCAGCCTCGCGCTGCGTCCCGGCGGCGCCTATGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTGTCGGCGCACCGGATCCGGCTGGCGATGGCCGTCCGCGCGAAGAATGCGCACT
GGAAAATGCAGGACATCCAGCGGCGCCACTGGCTGGGCCTGGGCCAACGCTACGGCCTCGTCACGTCCGATGGCGCGGAT
ACCGCCTCCATCGTGGACAACCTGGTGACCCGCACGCCCGAGGTGATCCGCACCGTGCGCGCGATGCTGCCGGAAGGCTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCAGGGGCTGCAGCACGCCGCGGACAAACTCGCGGGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9741.29 Da        Isoelectric Point: 11.3760

>AT77350 WP_064046647.1 NZ_CP021767:1683247-1683513 [Ralstonia solanacearum]
MNEFIVRTPEQLPAILKGFRKQAGLSQAELATRMGMRQQTLSALERNTENVSAARLMRLLSVLGVELVLRKPNAAGEPGR
PASDQPQW

Download         Length: 267 bp

>AT77350 NZ_CP021767:1683247-1683513 [Ralstonia solanacearum]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATCCTCAAGGGCTTCCGCAAACAGGCCGGGCTGAGCCA
AGCCGAACTGGCCACCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGCTGGAGCGCAACACAGAAAACGTAAGCGCCG
CTCGGCTGATGCGCCTGCTGTCGGTGCTGGGCGTGGAACTGGTGCTGCGCAAACCCAACGCCGCCGGCGAGCCCGGCCGC
CCGGCATCCGACCAGCCGCAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References