Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1031960..1032504 Replicon plasmid unnamed
Accession NZ_CP021767
Organism Ralstonia solanacearum strain RS 489

Toxin (Protein)


Gene name relE Uniprot ID D8P457
Locus tag CDC59_RS19995 Protein ID WP_013208202.1
Coordinates 1032229..1032504 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D8P456
Locus tag CDC59_RS19990 Protein ID WP_013208201.1
Coordinates 1031960..1032229 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC59_RS19965 1027126..1028355 - 1230 WP_013208193.1 efflux RND transporter periplasmic adaptor subunit -
CDC59_RS19970 1028718..1029596 - 879 WP_097909518.1 EamA family transporter -
CDC59_RS19975 1029875..1030122 + 248 Protein_792 hypothetical protein -
CDC59_RS19980 1030256..1030639 + 384 WP_042591092.1 hypothetical protein -
CDC59_RS19985 1030682..1031578 - 897 WP_064046417.1 LysR family transcriptional regulator -
CDC59_RS19990 1031960..1032229 + 270 WP_013208201.1 ribbon-helix-helix domain-containing protein Antitoxin
CDC59_RS19995 1032229..1032504 + 276 WP_013208202.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDC59_RS20000 1032618..1033538 - 921 WP_064046407.1 spermidine synthase -
CDC59_RS20005 1033768..1034703 + 936 WP_064046418.1 5-dehydro-4-deoxyglucarate dehydratase -
CDC59_RS20010 1034735..1036321 + 1587 WP_064046408.1 aldehyde dehydrogenase (NADP(+)) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cheY / cyaB / flgG / fliM / fliI / acrB / adeG / cheY / cheB / cheW / motA 1..1999547 1999547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10806.56 Da        Isoelectric Point: 9.5036

>T77349 WP_013208202.1 NZ_CP021767:1032229-1032504 [Ralstonia solanacearum]
MELKWTSKALSDVARLYEFLAPVNKPAAARTVQALIKAPTILLTNPRVGEQLFQFEPREVRRMLVGQYEMRYELQDETIY
VLRLWHTREDR

Download         Length: 276 bp

>T77349 NZ_CP021767:1032229-1032504 [Ralstonia solanacearum]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGACGTGGCGCGCTTGTATGAATTCCTGGCCCCTGTAAACAAACCAGC
GGCCGCTCGGACAGTGCAGGCGCTGATCAAGGCCCCGACCATTCTGCTGACCAACCCGCGCGTTGGCGAACAACTCTTTC
AGTTCGAGCCGCGCGAGGTGCGTCGGATGCTGGTCGGCCAGTACGAGATGCGCTACGAACTCCAGGACGAGACGATCTAC
GTGCTGCGGCTGTGGCACACCAGGGAGGATCGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10020.29 Da        Isoelectric Point: 4.8616

>AT77349 WP_013208201.1 NZ_CP021767:1031960-1032229 [Ralstonia solanacearum]
MPKAETRVLTAHVPVPLAEKVDQLAERLERSRGWIMKQALSAWIGQEEERDRLTHEALADVDGGRVIDHQAVQAWADSLS
TDEPLQVPR

Download         Length: 270 bp

>AT77349 NZ_CP021767:1031960-1032229 [Ralstonia solanacearum]
ATGCCTAAAGCCGAAACACGCGTGCTGACCGCGCACGTTCCCGTTCCCCTTGCCGAGAAGGTTGACCAATTGGCTGAACG
CCTCGAACGCTCGCGCGGCTGGATTATGAAACAGGCGCTCTCGGCTTGGATCGGCCAGGAGGAAGAGCGCGACCGCTTGA
CCCACGAGGCGCTGGCTGACGTGGATGGCGGCCGCGTCATCGACCATCAGGCTGTTCAGGCGTGGGCGGATAGCCTGAGT
ACTGACGAACCGCTGCAGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A177RHM3

Antitoxin

Source ID Structure
AlphaFold DB A0A177RGQ6

References