Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 469972..470605 Replicon chromosome
Accession NZ_CP021766
Organism Ralstonia solanacearum strain RS 489

Toxin (Protein)


Gene name vapC Uniprot ID A0A850FL68
Locus tag CDC59_RS02010 Protein ID WP_003263272.1
Coordinates 470192..470605 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F6FXL0
Locus tag CDC59_RS02005 Protein ID WP_003263271.1
Coordinates 469972..470205 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC59_RS01990 465549..466838 - 1290 WP_003263268.1 MFS transporter -
CDC59_RS01995 466846..468111 - 1266 WP_097908753.1 AGE family epimerase/isomerase -
CDC59_RS02000 468307..469914 + 1608 WP_097908755.1 glucan biosynthesis protein -
CDC59_RS02005 469972..470205 + 234 WP_003263271.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDC59_RS02010 470192..470605 + 414 WP_003263272.1 PIN domain-containing protein Toxin
CDC59_RS02015 470580..471206 - 627 WP_097908757.1 DUF1415 domain-containing protein -
CDC59_RS02020 471418..471789 + 372 WP_097908759.1 hypothetical protein -
CDC59_RS02025 471865..473361 - 1497 WP_042590881.1 glycerol kinase GlpK -
CDC59_RS02030 473533..475269 - 1737 WP_042590880.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-40)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14843.14 Da        Isoelectric Point: 5.9701

>T77346 WP_003263272.1 NZ_CP021766:470192-470605 [Ralstonia solanacearum]
MPAAEAFFDSNIVLYLLSADAAKADAAEALLMAGGAVSVQVLNETTHVMRRKLAMPWHAIEAVQEAVRAQCRVEPLTVET
HDLGRHLAQRYGLSVYDALIVAAASLAGCRVLYSEDMQHGLVIEQRLRVVNPFVASA

Download         Length: 414 bp

>T77346 NZ_CP021766:470192-470605 [Ralstonia solanacearum]
ATGCCCGCGGCTGAGGCGTTTTTCGACAGCAACATCGTGCTGTACCTGCTGTCGGCCGATGCCGCCAAGGCCGATGCGGC
GGAAGCGCTACTGATGGCCGGCGGTGCCGTCAGCGTGCAGGTGCTCAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAGCGGTGCAGGAAGCTGTGCGCGCGCAATGCCGGGTCGAGCCGCTGACGGTCGAAACC
CATGATCTCGGGCGGCATCTTGCGCAGCGCTATGGATTGTCGGTCTATGACGCGCTGATCGTCGCCGCGGCGTCGCTGGC
CGGTTGCCGCGTTCTGTATTCCGAGGACATGCAGCACGGCCTGGTGATCGAGCAGCGTCTGCGCGTCGTCAATCCTTTTG
TCGCGTCGGCGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8664.82 Da        Isoelectric Point: 8.7288

>AT77346 WP_003263271.1 NZ_CP021766:469972-470205 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALGLHEGDDVEVVVAGERSFGVRRKRSARELFERLHQYRGKLPADFIFERDDANARG

Download         Length: 234 bp

>AT77346 NZ_CP021766:469972-470205 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCCATCCGGCTGCCCGCAGCCGTCGTGGAGGCGCTTGGACTGCACGAAGG
CGACGACGTCGAGGTGGTGGTGGCGGGCGAACGCTCGTTTGGTGTGCGCCGCAAGCGTTCCGCGCGTGAGTTGTTTGAGC
GGCTCCACCAATACCGCGGCAAGCTGCCCGCCGACTTCATCTTCGAGCGCGACGACGCCAATGCCCGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A850FL68

Antitoxin

Source ID Structure
AlphaFold DB F6FXL0

References