Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3292248..3292881 Replicon chromosome
Accession NZ_CP021762
Organism Ralstonia pseudosolanacearum strain RS 476

Toxin (Protein)


Gene name vapC Uniprot ID Q8XUX8
Locus tag CDC45_RS15665 Protein ID WP_011002948.1
Coordinates 3292248..3292661 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag CDC45_RS15670 Protein ID WP_011002949.1
Coordinates 3292648..3292881 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDC45_RS15645 3287624..3289366 + 1743 WP_011002944.1 ABC transporter substrate-binding protein -
CDC45_RS15650 3289528..3291024 + 1497 WP_011002945.1 glycerol kinase GlpK -
CDC45_RS15655 3291085..3291456 - 372 WP_011002946.1 hypothetical protein -
CDC45_RS15660 3291647..3292273 + 627 WP_011002947.1 DUF1415 domain-containing protein -
CDC45_RS15665 3292248..3292661 - 414 WP_011002948.1 PIN domain-containing protein Toxin
CDC45_RS15670 3292648..3292881 - 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CDC45_RS15675 3292938..3294545 - 1608 WP_043876668.1 glucan biosynthesis protein D -
CDC45_RS15680 3294740..3295990 + 1251 WP_119918750.1 AGE family epimerase/isomerase -
CDC45_RS15685 3295998..3297293 + 1296 WP_011002952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15101.45 Da        Isoelectric Point: 5.5348

>T77344 WP_011002948.1 NZ_CP021762:c3292661-3292248 [Ralstonia pseudosolanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVTVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

>T77344 NZ_CP021762:c3292661-3292248 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCACCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGATGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT77344 WP_011002949.1 NZ_CP021762:c3292881-3292648 [Ralstonia pseudosolanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp

>AT77344 NZ_CP021762:c3292881-3292648 [Ralstonia pseudosolanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8XUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References