Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3753799..3754315 Replicon chromosome
Accession NZ_CP021757
Organism Klebsiella pneumoniae strain AR_0138

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag AM385_RS18930 Protein ID WP_009486548.1
Coordinates 3754031..3754315 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM385_RS18925 Protein ID WP_002886901.1
Coordinates 3753799..3754041 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM385_RS18910 3749827..3750567 + 741 WP_009486551.1 KDGP aldolase family protein -
AM385_RS18915 3750634..3751788 + 1155 WP_002886900.1 lactonase family protein -
AM385_RS18920 3751811..3753721 + 1911 WP_009486549.1 BglG family transcription antiterminator -
AM385_RS18925 3753799..3754041 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM385_RS18930 3754031..3754315 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM385_RS18935 3754319..3754783 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM385_RS18940 3755091..3757229 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM385_RS18945 3757586..3758329 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM385_RS29590 3758332..3758505 - 174 WP_032433782.1 hypothetical protein -
AM385_RS18950 3758590..3758898 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T77337 WP_009486548.1 NZ_CP021757:3754031-3754315 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T77337 NZ_CP021757:3754031-3754315 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT77337 WP_002886901.1 NZ_CP021757:3753799-3754041 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT77337 NZ_CP021757:3753799-3754041 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References