Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3809026..3809683 | Replicon | chromosome |
Accession | NZ_CP021749 | ||
Organism | Enterobacter cloacae complex sp. strain AR_0163 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A7T9SH06 |
Locus tag | AM409_RS18930 | Protein ID | WP_023295382.1 |
Coordinates | 3809273..3809683 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | G8LDB7 |
Locus tag | AM409_RS18925 | Protein ID | WP_003863437.1 |
Coordinates | 3809026..3809292 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM409_RS18905 (AM409_18815) | 3804432..3805865 | - | 1434 | WP_045910760.1 | 6-phospho-beta-glucosidase | - |
AM409_RS18910 (AM409_18820) | 3805982..3806713 | - | 732 | WP_015571796.1 | MurR/RpiR family transcriptional regulator | - |
AM409_RS18915 (AM409_18825) | 3806980..3807639 | + | 660 | WP_003863433.1 | hemolysin III family protein | - |
AM409_RS18920 (AM409_18830) | 3807751..3808731 | - | 981 | WP_022649306.1 | tRNA-modifying protein YgfZ | - |
AM409_RS18925 (AM409_18835) | 3809026..3809292 | + | 267 | WP_003863437.1 | FAD assembly factor SdhE | Antitoxin |
AM409_RS18930 (AM409_18840) | 3809273..3809683 | + | 411 | WP_023295382.1 | protein YgfX | Toxin |
AM409_RS18935 (AM409_18845) | 3809685..3810206 | - | 522 | WP_015571793.1 | flavodoxin FldB | - |
AM409_RS18940 (AM409_18850) | 3810307..3811203 | + | 897 | WP_003863442.1 | site-specific tyrosine recombinase XerD | - |
AM409_RS18945 (AM409_18855) | 3811232..3811945 | + | 714 | WP_003863443.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
AM409_RS18950 (AM409_18860) | 3811951..3813684 | + | 1734 | WP_017382886.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16291.18 Da Isoelectric Point: 11.4775
>T77288 WP_023295382.1 NZ_CP021749:3809273-3809683 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE
Download Length: 411 bp
>T77288 NZ_CP021749:3809273-3809683 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCAGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCAGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10526.96 Da Isoelectric Point: 4.8310
>AT77288 WP_003863437.1 NZ_CP021749:3809026-3809292 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI
Download Length: 267 bp
>AT77288 NZ_CP021749:3809026-3809292 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7T9SH06 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837F8P5 |