Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3809026..3809683 Replicon chromosome
Accession NZ_CP021749
Organism Enterobacter cloacae complex sp. strain AR_0163

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T9SH06
Locus tag AM409_RS18930 Protein ID WP_023295382.1
Coordinates 3809273..3809683 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM409_RS18925 Protein ID WP_003863437.1
Coordinates 3809026..3809292 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM409_RS18905 (AM409_18815) 3804432..3805865 - 1434 WP_045910760.1 6-phospho-beta-glucosidase -
AM409_RS18910 (AM409_18820) 3805982..3806713 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
AM409_RS18915 (AM409_18825) 3806980..3807639 + 660 WP_003863433.1 hemolysin III family protein -
AM409_RS18920 (AM409_18830) 3807751..3808731 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM409_RS18925 (AM409_18835) 3809026..3809292 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM409_RS18930 (AM409_18840) 3809273..3809683 + 411 WP_023295382.1 protein YgfX Toxin
AM409_RS18935 (AM409_18845) 3809685..3810206 - 522 WP_015571793.1 flavodoxin FldB -
AM409_RS18940 (AM409_18850) 3810307..3811203 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM409_RS18945 (AM409_18855) 3811232..3811945 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM409_RS18950 (AM409_18860) 3811951..3813684 + 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16291.18 Da        Isoelectric Point: 11.4775

>T77288 WP_023295382.1 NZ_CP021749:3809273-3809683 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGAPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T77288 NZ_CP021749:3809273-3809683 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCAGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT77288 WP_003863437.1 NZ_CP021749:3809026-3809292 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT77288 NZ_CP021749:3809026-3809292 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7T9SH06


Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References