Detailed information of TA system TA077280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1886..2913
• Replicon: plasmid pSU3
• Accession: NZ_CP021747
• Organism: Agarilytica rhodophyticola strain 017

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: BVC89_RS29260
• Protein ID: WP_103654485.1
• Coordinates: 2341..2913 (+)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: BVC89_RS29255
• Protein ID: WP_103654484.1
• Coordinates: 1886..2344 (+)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVC89_RS29240	115..465	+	351	WP_103654482.1	hypothetical protein	-
BVC89_RS29245	795..1529	+	735	WP_103654526.1	SprT-like domain-containing protein	-
BVC89_RS29255	1886..2344	+	459	WP_103654484.1	excisionase family DNA-binding protein	Antitoxin
BVC89_RS29260	2341..2913	+	573	WP_103654485.1	PIN domain-containing protein	Toxin
BVC89_RS29265	3129..3578	+	450	WP_158658206.1	YkgJ family cysteine cluster protein	-
BVC89_RS29270	3590..4552	+	963	WP_103654486.1	hypothetical protein	-
BVC89_RS29275	4671..4949	+	279	WP_103654487.1	DUF1778 domain-containing protein	-
BVC89_RS29280	4972..5190	-	219	WP_103654488.1	hypothetical protein	-
BVC89_RS29285	5198..5785	-	588	WP_103654489.1	hypothetical protein	-
BVC89_RS29290	5808..6422	-	615	WP_103654490.1	hypothetical protein	-
BVC89_RS29295	6540..7142	-	603	WP_103654491.1	hypothetical protein	-
BVC89_RS29300	7146..7727	-	582	WP_103654492.1	AHH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..31527	31527

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (81-125)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21783.33 Da
• Isoelectric Point: 6.7483

>T77280 WP_103654485.1 NZ_CP021747:2341-2913 [Agarilytica rhodophyticola]
MTSNFTVVYDACVMYPAPLRSFLMYLALTDMFRARWSDMIHDEWIRNLLANRPDLTQKQLTRTKDLMNANVRGCLVSGFE
PLIEAVELPDPDDRHVVAAAIHTRAEAIVTFNLKDFPDRALDKFNLKAIHPDEFIMDLMDLHIGTVIEAARTHRQSLKNP
PFTADAYLDCLLKQQLPQSVSRLRALKVML

Nucleotide

• Length: 573 bp

>T77280 NZ_CP021747:2341-2913 [Agarilytica rhodophyticola]
ATGACTTCCAATTTCACAGTTGTCTATGATGCATGCGTGATGTATCCCGCCCCATTGCGGAGCTTTCTTATGTACCTAGC
TTTGACGGATATGTTCAGAGCTAGGTGGTCGGATATGATCCATGATGAATGGATCCGTAACTTACTAGCAAATCGGCCAG
ATTTAACTCAGAAACAGCTTACTCGCACGAAAGACCTAATGAATGCCAACGTTAGGGGATGTTTAGTTTCCGGGTTTGAG
CCGCTTATAGAAGCCGTTGAGCTTCCCGATCCAGACGACCGCCATGTGGTGGCCGCCGCAATACATACGCGCGCAGAAGC
GATCGTAACGTTTAATTTAAAGGACTTCCCAGACCGCGCACTAGATAAATTCAATTTAAAGGCTATTCACCCAGACGAAT
TCATCATGGATTTAATGGATCTCCATATCGGTACCGTGATCGAGGCAGCCAGAACACACCGCCAAAGCTTAAAGAACCCG
CCTTTTACGGCAGATGCTTACCTAGATTGCCTACTCAAACAACAGTTGCCACAAAGTGTTTCTCGGCTAAGAGCACTTAA
AGTAATGCTATAA

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 16849.25 Da
• Isoelectric Point: 5.0288

>AT77280 WP_103654484.1 NZ_CP021747:1886-2344 [Agarilytica rhodophyticola]
MNLLQEKLPTPEEAALAKLSSRELSAFLETKADSQAVSITDKEGIAHAVEIPVSALRLLVEVLTQLGEGNTVNLIPVHAQ
LTTQEGADILNVSRPTFIKLLDDEKIPYHRVGNRRKVAFSDVLNYKHDIDKKRLASLSELSELDQAMNMGYE

Nucleotide

• Length: 459 bp

>AT77280 NZ_CP021747:1886-2344 [Agarilytica rhodophyticola]
ATGAACCTCCTACAAGAAAAGCTACCTACACCAGAAGAAGCAGCACTGGCAAAACTGTCCAGCCGCGAGTTGTCTGCTTT
CTTGGAGACAAAAGCAGACTCACAAGCCGTAAGCATCACCGATAAAGAGGGTATCGCGCACGCAGTCGAAATTCCTGTTA
GCGCTCTCCGTCTCCTGGTTGAAGTATTAACACAACTTGGAGAAGGTAATACGGTTAACCTTATACCCGTCCATGCTCAG
CTTACAACTCAAGAGGGTGCCGACATACTTAACGTATCTCGACCCACGTTTATAAAGCTACTGGATGATGAAAAAATTCC
TTATCATCGTGTCGGTAACAGGCGTAAAGTCGCCTTTTCTGATGTGCTGAACTACAAGCATGACATCGATAAGAAGCGCC
TAGCGTCGCTCTCTGAGCTCTCTGAGCTCGACCAAGCAATGAATATGGGATACGAATGA