Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5206959..5207616 Replicon chromosome
Accession NZ_CP021740
Organism Klebsiella pneumoniae strain AR_0126

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM373_RS25985 Protein ID WP_002916310.1
Coordinates 5206959..5207369 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM373_RS25990 Protein ID WP_002916312.1
Coordinates 5207350..5207616 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM373_RS25965 5202959..5204692 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
AM373_RS25970 5204698..5205411 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM373_RS25975 5205434..5206330 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM373_RS25980 5206431..5206952 + 522 WP_002916308.1 flavodoxin FldB -
AM373_RS25985 5206959..5207369 - 411 WP_002916310.1 protein YgfX Toxin
AM373_RS25990 5207350..5207616 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM373_RS25995 5207862..5208845 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AM373_RS26000 5208996..5209655 - 660 WP_002916317.1 hemolysin III family protein -
AM373_RS26005 5209819..5210130 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
AM373_RS26010 5210180..5210908 + 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
AM373_RS26015 5211027..5212460 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T77278 WP_002916310.1 NZ_CP021740:c5207369-5206959 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T77278 NZ_CP021740:c5207369-5206959 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT77278 WP_002916312.1 NZ_CP021740:c5207616-5207350 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT77278 NZ_CP021740:c5207616-5207350 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References