Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1247430..1247946 Replicon chromosome
Accession NZ_CP021740
Organism Klebsiella pneumoniae strain AR_0126

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag AM373_RS06335 Protein ID WP_009486548.1
Coordinates 1247662..1247946 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM373_RS06330 Protein ID WP_002886901.1
Coordinates 1247430..1247672 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM373_RS06315 1243458..1244198 + 741 WP_009486551.1 KDGP aldolase family protein -
AM373_RS06320 1244265..1245419 + 1155 WP_020316350.1 lactonase family protein -
AM373_RS06325 1245442..1247352 + 1911 WP_009486549.1 BglG family transcription antiterminator -
AM373_RS06330 1247430..1247672 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM373_RS06335 1247662..1247946 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM373_RS06340 1247950..1248414 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM373_RS06345 1248722..1250860 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AM373_RS06350 1251217..1251960 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM373_RS28715 1251963..1252136 - 174 WP_002886906.1 hypothetical protein -
AM373_RS06355 1252221..1252529 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T77266 WP_009486548.1 NZ_CP021740:1247662-1247946 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T77266 NZ_CP021740:1247662-1247946 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT77266 WP_002886901.1 NZ_CP021740:1247430-1247672 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT77266 NZ_CP021740:1247430-1247672 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References