Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1042562..1043394 Replicon chromosome
Accession NZ_CP021736
Organism Escherichia coli strain AR_0150

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag AM397_RS05130 Protein ID WP_000854765.1
Coordinates 1043020..1043394 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag AM397_RS05125 Protein ID WP_001295723.1
Coordinates 1042562..1042930 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM397_RS05085 1038226..1038906 + 681 WP_001282921.1 WYL domain-containing protein -
AM397_RS05090 1039054..1039731 + 678 WP_001097302.1 hypothetical protein -
AM397_RS05095 1039737..1039970 + 234 WP_001278293.1 DUF905 family protein -
AM397_RS05100 1040060..1040878 + 819 WP_001175165.1 DUF945 domain-containing protein -
AM397_RS05105 1041144..1041623 + 480 WP_057109541.1 antirestriction protein -
AM397_RS05110 1041639..1042115 + 477 WP_001186774.1 RadC family protein -
AM397_RS05115 1042178..1042399 + 222 WP_000692341.1 DUF987 domain-containing protein -
AM397_RS05125 1042562..1042930 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM397_RS05130 1043020..1043394 + 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
AM397_RS05135 1043394..1043597 + 204 WP_001398797.1 hypothetical protein -
AM397_RS05140 1043622..1043816 + 195 WP_024181941.1 DUF957 domain-containing protein -
AM397_RS05145 1043901..1044743 + 843 WP_022645115.1 DUF4942 domain-containing protein -
AM397_RS05150 1045024..1045560 - 537 WP_000942785.1 GspM family type II secretion system protein YghD -
AM397_RS05155 1045562..1046740 - 1179 WP_000094991.1 type II secretion system protein GspL -
AM397_RS05160 1046737..1047714 - 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
AM397_RS05165 1047717..1048316 - 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T77230 WP_000854765.1 NZ_CP021736:1043020-1043394 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T77230 NZ_CP021736:1043020-1043394 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT77230 WP_001295723.1 NZ_CP021736:1042562-1042930 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT77230 NZ_CP021736:1042562-1042930 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7ZVJ9


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References