Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 4139821..4140485 Replicon chromosome
Accession NZ_CP021731
Organism Azoarcus sp. DN11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDA09_RS19225 Protein ID WP_121430114.1
Coordinates 4140078..4140485 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CDA09_RS19220 Protein ID WP_121430948.1
Coordinates 4139821..4140081 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDA09_RS19170 4134855..4135271 + 417 WP_121430945.1 type IVa pilus major pilin TapA -
CDA09_RS19175 4135581..4135814 + 234 WP_121430107.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CDA09_RS19180 4135811..4136197 + 387 WP_121430108.1 type II toxin-antitoxin system VapC family toxin -
CDA09_RS19185 4136201..4136302 - 102 WP_121430946.1 hypothetical protein -
CDA09_RS19190 4136520..4136801 + 282 WP_121430947.1 type II toxin-antitoxin system ParD family antitoxin -
CDA09_RS19195 4136801..4137127 + 327 WP_121430109.1 type II toxin-antitoxin system RelE/ParE family toxin -
CDA09_RS19200 4137312..4137557 + 246 WP_121430110.1 hypothetical protein -
CDA09_RS19205 4137562..4137960 + 399 WP_121430111.1 type II toxin-antitoxin system VapC family toxin -
CDA09_RS19210 4138147..4138476 + 330 WP_121430112.1 putative addiction module antidote protein -
CDA09_RS19215 4138606..4139709 + 1104 WP_121430113.1 transposase -
CDA09_RS19220 4139821..4140081 + 261 WP_121430948.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CDA09_RS19225 4140078..4140485 + 408 WP_121430114.1 type II toxin-antitoxin system VapC family toxin Toxin
CDA09_RS19230 4140715..4141545 + 831 WP_121430115.1 hypothetical protein -
CDA09_RS19235 4141686..4143083 - 1398 WP_121430116.1 sigma-54 dependent transcriptional regulator -
CDA09_RS19240 4143080..4144648 - 1569 WP_121430117.1 PAS domain-containing sensor histidine kinase -
CDA09_RS19245 4144651..4144905 - 255 WP_121430118.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4131309..4140485 9176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-50)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15116.39 Da        Isoelectric Point: 7.3189

>T77189 WP_121430114.1 NZ_CP021731:4140078-4140485 [Azoarcus sp. DN11]
MILLDTVILSELRKRTPSAAVVNWLKAHKDDELFISVVSIGEIERGIEKRRRADPAFAETLTTWLEDLLRYYTDRVLPIT
PGIARRWGALSARIGNESADLLIAATALYHGLTVATRNVRHFTPTGVATMNPFDD

Download         Length: 408 bp

>T77189 NZ_CP021731:4140078-4140485 [Azoarcus sp. DN11]
ATGATTTTGCTCGATACCGTTATCTTGTCGGAACTGCGCAAGCGCACGCCCTCCGCCGCAGTCGTGAATTGGCTGAAAGC
GCACAAGGATGACGAATTGTTCATCAGCGTCGTAAGTATCGGCGAGATCGAACGAGGGATCGAAAAGCGACGCCGTGCGG
ATCCGGCATTTGCTGAAACGCTCACAACCTGGCTCGAAGACCTCCTGCGCTATTACACCGATCGCGTATTACCGATCACT
CCCGGGATTGCCCGCCGATGGGGTGCGCTGTCCGCGAGAATCGGCAACGAAAGCGCGGACTTGCTGATTGCGGCGACGGC
CCTGTATCACGGACTCACAGTCGCCACCCGCAACGTTCGCCATTTCACGCCGACCGGCGTAGCGACGATGAATCCGTTTG
ACGATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9542.72 Da        Isoelectric Point: 6.6419

>AT77189 WP_121430948.1 NZ_CP021731:4139821-4140081 [Azoarcus sp. DN11]
MNRQWRLQDAKTHLSQVVEGALHGTPQHITRRGKAAVVVLSEGEYARLIRNAQTSAPGFVAHLLAIPQEADTFEHGDVAL
RDVDFE

Download         Length: 261 bp

>AT77189 NZ_CP021731:4139821-4140081 [Azoarcus sp. DN11]
ATGAACCGGCAATGGCGGCTGCAGGATGCCAAGACCCACTTGAGCCAAGTGGTCGAGGGCGCATTGCACGGTACTCCGCA
GCACATCACGCGCCGCGGCAAGGCGGCCGTGGTCGTACTTTCCGAAGGTGAATATGCGCGATTGATACGCAATGCGCAAA
CCAGCGCACCGGGGTTTGTTGCGCATCTGCTGGCGATACCCCAGGAGGCGGATACATTCGAGCACGGCGATGTGGCGCTC
AGGGATGTCGATTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References