Detailed information of TA system TA077188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4129900..4130444
• Replicon: chromosome
• Accession: NZ_CP021731
• Organism: Azoarcus sp. DN11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CDA09_RS19110
• Protein ID: WP_121430098.1
• Coordinates: 4130169..4130444 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CDA09_RS19105
• Protein ID: WP_121430097.1
• Coordinates: 4129900..4130169 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDA09_RS19095	4125094..4126635	+	1542	WP_121430095.1	efflux RND transporter periplasmic adaptor subunit	-
CDA09_RS19100	4126649..4129792	+	3144	WP_121430096.1	efflux RND transporter permease subunit	-
CDA09_RS19105	4129900..4130169	+	270	WP_121430097.1	ribbon-helix-helix domain-containing protein	Antitoxin
CDA09_RS19110	4130169..4130444	+	276	WP_121430098.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CDA09_RS19115	4130830..4131312	-	483	WP_121430099.1	hypothetical protein	-
CDA09_RS19120	4131309..4131608	-	300	WP_164844442.1	nucleotidyltransferase domain-containing protein	-
CDA09_RS19125	4131822..4132235	-	414	WP_121430100.1	putative toxin-antitoxin system toxin component, PIN family	-
CDA09_RS19130	4132228..4132476	-	249	WP_121430101.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CDA09_RS19135	4132733..4133017	+	285	WP_121430944.1	nucleotidyltransferase domain-containing protein	-
CDA09_RS19145	4133215..4133478	-	264	WP_121430102.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CDA09_RS19150	4133465..4133698	-	234	WP_121430103.1	ribbon-helix-helix protein, CopG family	-
CDA09_RS19155	4133889..4134275	-	387	WP_121430104.1	type II toxin-antitoxin system VapC family toxin	-
CDA09_RS19160	4134272..4134520	-	249	WP_121430105.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
CDA09_RS19170	4134855..4135271	+	417	WP_121430945.1	type IVa pilus major pilin TapA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10684.29 Da
• Isoelectric Point: 9.9718

>T77188 WP_121430098.1 NZ_CP021731:4130169-4130444 [Azoarcus sp. DN11]
MELKWTNKALSDLARLYEFLAPVNRTAAARTIQSLTSAPASLVANPRIGERLDEFAPREVRRILVGHYEMRYEIREATLY
VLRLWHTREDR

Nucleotide

• Length: 276 bp

>T77188 NZ_CP021731:4130169-4130444 [Azoarcus sp. DN11]
ATGGAACTGAAATGGACGAACAAGGCGCTGTCGGATCTGGCGCGGCTGTACGAGTTTCTCGCGCCGGTTAATCGAACCGC
CGCGGCGCGTACCATCCAGTCGCTCACGTCTGCACCGGCCAGCCTCGTGGCGAACCCGCGCATCGGCGAACGGCTCGACG
AATTCGCACCGCGCGAAGTCCGCCGCATCCTTGTCGGGCACTACGAAATGCGCTACGAGATCCGGGAAGCCACGCTTTAC
GTGCTGCGGCTCTGGCATACGCGCGAAGACCGGTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9989.40 Da
• Isoelectric Point: 4.8307

>AT77188 WP_121430097.1 NZ_CP021731:4129900-4130169 [Azoarcus sp. DN11]
MAQTETKVLTAHVPRPLAEKVDLMAARLERSRGWIMKQALAAWIDQEEERSRLTREALADVDGACVIDHQAVQAWADSLE
TDTPLPLPR

Nucleotide

• Length: 270 bp

>AT77188 NZ_CP021731:4129900-4130169 [Azoarcus sp. DN11]
ATGGCACAGACAGAAACCAAAGTTCTAACCGCCCATGTGCCGCGCCCTCTTGCCGAGAAGGTCGACCTGATGGCCGCGCG
CCTTGAACGCTCACGCGGCTGGATCATGAAGCAGGCGCTGGCTGCGTGGATTGATCAGGAAGAAGAACGCAGCCGCCTGA
CCCGCGAGGCCCTGGCGGACGTTGATGGCGCGTGCGTCATCGACCACCAGGCCGTGCAGGCATGGGCCGACAGCCTGGAA
ACCGACACCCCGTTACCGTTGCCGCGCTGA