Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2140085..2140686 Replicon chromosome
Accession NZ_CP021731
Organism Azoarcus sp. DN11

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CDA09_RS09760 Protein ID WP_121428441.1
Coordinates 2140085..2140381 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CDA09_RS09765 Protein ID WP_121428442.1
Coordinates 2140387..2140686 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDA09_RS09745 2135510..2136979 + 1470 WP_121428438.1 FAD-dependent oxidoreductase -
CDA09_RS09750 2137442..2139262 + 1821 WP_121428439.1 AIPR family protein -
CDA09_RS09755 2139348..2139956 + 609 WP_128106553.1 hypothetical protein -
CDA09_RS09760 2140085..2140381 + 297 WP_121428441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CDA09_RS09765 2140387..2140686 + 300 WP_121428442.1 putative addiction module antidote protein Antitoxin
CDA09_RS09770 2140856..2142280 - 1425 WP_121428443.1 MFS transporter -
CDA09_RS09775 2142528..2143592 - 1065 WP_121428444.1 alkene reductase -
CDA09_RS09780 2143605..2144234 - 630 WP_174718430.1 nuclear transport factor 2 family protein -
CDA09_RS09785 2144246..2145013 - 768 WP_121428446.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10948.62 Da        Isoelectric Point: 10.1496

>T77187 WP_121428441.1 NZ_CP021731:2140085-2140381 [Azoarcus sp. DN11]
MVEIRKTEIFAQWLDALRDIQARARVQARIERLAGGNPGDVEPIGEGVSELRINYGPGCRVYFKQRGRELIILLASGDKS
TQAKDIKAALRLARNLSE

Download         Length: 297 bp

>T77187 NZ_CP021731:2140085-2140381 [Azoarcus sp. DN11]
ATGGTCGAAATTCGGAAAACCGAGATTTTCGCTCAGTGGCTCGACGCCTTGCGCGACATCCAGGCGCGGGCGCGAGTCCA
AGCCAGAATCGAGCGTCTTGCCGGTGGAAATCCCGGCGACGTCGAGCCCATTGGCGAAGGTGTTTCCGAGCTGCGAATCA
ATTATGGTCCCGGTTGCCGGGTGTATTTCAAGCAGCGAGGGCGTGAGTTGATCATCCTTCTGGCCAGTGGTGACAAGAGC
ACTCAAGCAAAAGACATCAAGGCGGCCTTGCGTCTCGCGCGAAACCTGTCGGAGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10518.94 Da        Isoelectric Point: 5.6334

>AT77187 WP_121428442.1 NZ_CP021731:2140387-2140686 [Azoarcus sp. DN11]
MAKTATTRYDVAEHLRTPEEMAAYLEACLEEADGDAAFIAKALGDIARAKGMAQVARDAGLSRESLYKALSGERSPGFDT
ILKVIGALGLKLHAEANHS

Download         Length: 300 bp

>AT77187 NZ_CP021731:2140387-2140686 [Azoarcus sp. DN11]
ATGGCCAAAACCGCTACCACTCGCTATGACGTTGCAGAGCACCTCCGAACCCCGGAGGAAATGGCGGCTTATCTTGAAGC
GTGCCTGGAAGAGGCAGATGGAGATGCTGCCTTTATTGCAAAAGCGCTTGGTGATATTGCCCGCGCCAAAGGCATGGCTC
AGGTCGCCAGAGATGCCGGGCTCTCCCGCGAAAGCCTCTACAAGGCTCTTTCGGGGGAACGCAGCCCTGGCTTTGACACG
ATCCTCAAGGTAATTGGTGCTCTCGGGCTGAAACTGCATGCCGAGGCCAACCATTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References